Hemolysis ciprofloxacin

Ciprofloxacin has been associated with hemolysis in combination with a severe skin reaction in a young adult (27). 

The withdrawal of temafloxacin in 1992, only 6 months after its introduction, followed the observation of serious adverse events that were labeled the temafloxacin syndrome (8). Adverse effects, including hemolysis, renal dysfunction, coagulopathy, and hepatic dysfunction, were estimated to occur in one in 3500 patients. For comparison, incidence rates for these adverse events were about one in 17 000 patients treated with ciprofloxacin and one in 33 000 patients treated with ofloxacin. 

In over 33 000 patients treated with ciprofloxacin, norfloxacin, or ofloxacin, no case of hemolytic anemia was discovered by prescription event monitoring (19). However, ciprofloxacin has been associated with hemolysis in combination with a severe skin reaction in a young adult (41). 

Hematologic A 30-year-old man took oral ciprofloxacin 1 g/day for 3 days for a suspected urinary tract infection and developed a rapidly fatal hemolytic anemia and severe thrombocytopenia [38 ]. The authors attributed the hemolysis and thrombocytopenia to ciprofloxacin, but a non-drug cause could not be ruled, since hematuria preceded exposure to ciprofloxacin. 

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