Hemoglobin Aic

Sugars can react with proteins to form, among others, hemoglobin Aic, a measure of blood glucose control over time. 

His most recent laboratory values show that his low-density lipoprotein (LDL) cholesterol is still slightly above goal at 120 mg/dL (goal < 100 mg/dL) and his hemoglobin Aic is well controlled at 6%. His blood pressure is also well controlled. His... 

Hyperinsulinemia is common in recipients of somatropin, but the long-term effects are controversial. This issue is becoming increasingly important as more adult patients are treated and the duration of therapy is extended. Growth hormone deficiency is itself associated with insulin resistance (36). Plasma concentrations of glucose and hemoglobin Aic increase, especially in the first 6-12... 

The importance of the amino terminal valyl residue for the binding of 2,3-DPG is indicated by the observation that hemoglobins with blocked amino terminal residues, such as the minor human hemoglobin Aic (B77) and one of the hemoglobins of the cat (Tl), and hemoglobins that lack this residue and thus have p chains with only 145 residues, such as the hemoglobin of sheep (B79), do not combine with this organic phosphate. 

Schnedl HJ> Reisinger EC, Pieber TR, Lipp RW, Schreiber F, Hopmeier P, et al. Hemoglobin Sherwood Forest detected by high performance liquid chromatography for hemoglobin Aic. Am J Clin Path 1995 104 444-6. 

The ADA recommends use of hemoglobin Aic (HbAic) determinations to monitor glycemic control in known diabetic patients. Because there is no gold standard assay and several countries do not have ready access to the test, an HbAic determination is not recommended to diagnose diabetes at the present time. 

Although the hemoglobin Aic assay is by far the more estabhshed in clinics than the fructosamine assay, the latter may be a good alternative in cases when accuracy of the former is compromised, as in anemia. The content of D-fructosated serum proteins, such as albumin, transferrin, or IgG, correlates with the overall fructosamine content and their separate analysis may also be used for diagnostic purposes, in both cUnical and veterinary practices. 

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