Heinz bodies, hematology

This study is supported by intermediate-duration NOAELs for hematological effects of 75 mg/kg/day in a dog study (Hart 1980) and 45 mg/kg/day (males) and 57 mg/kg/day (females) in a mink study (Bucci et al. 1997). In the Bucci et al. (1997) mink study, the next highest level, 262 or 330 mg/kg/day in males and females, respectively, produced hematological changes that included increased Heinz body counts, reticulocytes, mean cell volume, and decreased RBC counts. 

Hematological Effects. Hematological effects in a man, apparently exposed to cresol dermally while working with an antiseptic solution containing concentrated mixed cresols, included methemoglobinemia with massive hemolysis and the presence of numerous large Heinz bodies in the blood (Larcan et al. 1974). Similar effects have been reported following oral exposure to cresols (see Section 2.22.2). 

Fia. 11. Scheme of the pathogenesis of congenital Heinz body hemolytic anemia. From (J4), H. S. Jacob, Seminars in Hematology 341 (1970), with permission of the author and publisher. 

Following dermal application of DAAB in a 16 day study, animals exhibited symptoms that were similar to those from exposures to benzene and aniline. These symptoms included dose-related decreases in thymus weights in rats and mice and increases in the heart weights of rats and mice, liver and spleen in rats, and kidney in male rats and female mice. DAAB also induced hematologic effects in rats and mice, including Heinz-body formation and chemical-related methemoglobinemia. Induction of lymphoid atrophy of the thymus and other lymphoid tissues characteristic of benzene toxicity were also observed. Non-neoplastic lesions were observed in both rats and... 

Results from animal studies indicate that intermediate and chronic exposure to propylene glycol may lead to changes in hematological parameters and hemolysis of RBCs. Cats exposed to oral administration of propylene glycol developed Heinz bodies in RBCs and decreased RBC survival. Doses as low as 0.424 g kg bw per day have resulted in Heinz... 

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