Hedyotis capitellata

Phuong, N.M Sung, T.V Porzel, A Schmidt, J Merzweiler, K G, Adam. /Z-carboline alkaloids from Hedyotis capitellata. Phytochemistry. 1999, 52(8), 1725-1729. 

Phuong, N.M Sung, T.V Schmidt, J Porzel, A Adam, G. Capitelline, a new alkaloid from Hedyotis capitellata. Nat. Prod. Lett. 1998, 11,93-100. 

A number of alkaloids have been isolated from only three Hedyotis species, which are H. auricularia, H. chrysotricha and H. capitellata. The bis-indole alkaloids, hedyotine and auricularine were both isolated from the roots of H. auricularia [6,24]. However, the molecular formula and the structure of auricularine was revised later [19]. Auricularine (1) belongs to a novel group of bis-indole alkaloids, borreverine (lb) and isoborreverine [25] whose structures were established by X-ray crystallography and HRMS. Spectroscopic experiments found auricularine to differ from borreverine in its molecular formula by the presence of only a... 

An antibacterial assay using the disc-diffusion method found that the stems and the roots of H. capitellata showed weak to moderate activities against the tested bacteria, Bacillus subtilis B28, Bacillus subtilis B29, Pseudomonas aeruginosa UI 60690 and methicillin resistant Staphylococcus aureus, (MRSA) while the leaves showed weak activity toward Bacillus subtilis B28, MRSA and P. aeruginosa only. However, the roots of H. dichotoma showed moderate antibacterial properties against all four bacteria. All other extracts did not exhibit any antibacterial properties. Table 10 shows the inhibition zones of the methanolic extracts of some Hedyotis species as measured by the disc-diffusion method. 

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