Hypothermia heart rate

THC produces dose-dependent increases in heart rate and reductions in body temperature after injection, maximizing after 2 to 3 hours (table 10.6) (Heishman et al. 1989). Similarly, anandamide creates hypothermia in mice after injection (Pride and Mechoulam 1993). The cognitive effects of THC are dissociable from the autonomic effects (Bachman et al. 1979). 

As little as one teaspoon of GHB can result in an overdose, which can cause slowed heart rate, confusion, agitation, respiratory depression, seizures, loss of peripheral (outer) vision, agitation, hallucinations, hypothermia (low body temperature), nausea, vomiting, coma, and unconsciousness. The risk of a deadly overdose is increased if both coma and vomiting or coma and a blocked airway occur. 

A THC tetrahydrocannabinol is the major psychoactive ingredient in the Cannabisplant. A THC is responsible for both the psychiahic and therapeutic effects obtained from marijuana. Its receptor, the cannabinoid receptor, is located mainly tat the presynaptic gap. The areas of the brain most affected are the basal ganglia, cerebellum, cerebral cortex, and the hippocampus. The acute effects consist of degradation in short term memory, changes in sensory perception, reduced concenhation, disturbances in motor abilities, hypothermia, increased blood pressure and heart rate, and reduced pain perception. 

The estimated oral lethal dose for humans is 200-400 g. Oral doses of 10 g produce no obvious effect. Vital signs may include bradycardia (decreased heart rate), hypotension, hypothermia, miosis (small pupils), salivation and lacrimation (tearing), ocular pain, blurred vision, bronchospasm, muscle cramps, fasciculation (muscle twitching), weakness, nausea, vomiting, diarrhea, and involuntary urination. 

In a number of cases, actions of lobeline differed significantly from those of nicotine. For example, chronic treatment of mice with nicotine led to an increase in the number of brain nicotinic receptors, which was not seen with lobeline treatment [85], Unlike nicotine, lobeline pretreatment did not reduce hypothermia and locomotor suppression in mice, produced by a nicotine challenge [519]. Lobeline failed to elicit the "nicotine cue", a discriminative effect in rats [520], and produced a pharmacologic profile (including heart rate, blood pressure, respiratory rate, minute and tidal volume) which differed from nicotine [86], Such studies have led to the proposal that lobeline, in at least some of its effects, acts via a different mechanism than nicotine [86,519],... 

SY Irrit eyes, skin, nose, throat, upper resp sys methemo cyan, convuls restless, bluish skin, incr heart rate, dysp dizz, drow, hypothermia, hema spleen, kidney, liver changes derm... 

The first symptoms of hypothermia, shivering, an inability to do complex motor functions, lethargy, and mild confusion, occur as the core body temperature decreases to aroimd 95°F. The person can t complete even simple motor ftmctions, speech becomes slurred, and behavior may become irrational. The most severe state of h3rpothermia occiirs when body temperatiire falls below 90°F. As a result, the body moves into a state of hibernation, slowing the heart rate, blood flow, and breathing. Unconsciousness and full heart failure can occur in the severely h3rpothermic state. 

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