Interleukins heart diseases

Desreumaux, P., Janin, A., Dubucquoi, S., Copin, M. C., Torpier, G., Capron, A., Capron, M. and Prin, L. (1993). Synthesis of interleukin-5 by activated eosinophils in patients with eosinophilic heart diseases. Blood 82, 1553-1560. 

Tumor Necrosis Factor Alpha Tumor necrosis factor alpha (TNFa) is an inflammatory cytokine and interleukin that is involved in the genesis of sepsis, arthritis, and a variety of other inflammatory states (see Chapter 22). It also has hemodynamic effects and reduces ventricular performance. It is also a common signaling molecule. Assays for it or its receptor have been developed, but the failure of recent therapeutic trials has led to concern about how to properly interpret the high levels seen in patients with CHF and coronary heart disease. At present, there are no standardized assays and no reference interval studies or consistent assay validations. 

HRT Hormone-replacement therapy ICAM-1 Intercellular adhesion molecule IDE Intermediate-density lipoprotein IHD Ischemic heart disease IL Interleukin... 

Offenbacher, S. et al.. Association of coronary heart disease with interleukin 1 gene variants in the Atherosclerosis Risk in Communities Study, in The American College of Cardiology Annual Scientific Session, Abstract No. 1028-166, 2004. 

Galea, J., Armstrong, J., Gadsdon, P., Holden, H., Francis, S.E., and Holt, C.M. (1996) Interleukin-1 Beta in Coronary Arteries of Patients with Ischemic Heart Disease, Arterioscler. Throm. Vase. Biol. 16,1000 1006. 

Cardiovascniar In 95 patients with coronary heart disease and depression, who were randomized to sertraline (mean dosage 70 mg/day) or placebo over 20 weeks, sertraline significantly improved flow-dependent, endothelium-mediated dilatation of the brachial artery, while reducing the concentrations of C-reactive protein and interleukin-6 [17 ]. This suggests that sertraline has beneficial effects on the endothehum and immunological system, which could improve the prognosis of patients with depression and coronary heart disease. 

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