Healthcare complex

Many people who have experienced anaphylaxis in the community and are therefore at risk for recurrence have never received a prescription for an epinephrine autoinjector from an emergency department physician [38, 39] or from their primary care physician. Some of those who have received a prescription for an epinephrine autoinjector do not follow through and get it filled [40]. Even if they do get the epinephrine autoinjector dispensed, they may fail to carry it with them at all times [41]. Adherence to instructions to carry epinephrine can be improved with regular input from a healthcare professional [42] however, healthcare professionals need to master the complexities of epinephrine autoinjector use [43] before instructing others. People who have survived a mild anaphylaxis episode that was not treated at all, or was treated only with an antihistamine or an asthma puffer, sometimes fail to inject epinephrine because they erroneously assume that their subsequent reactions will also be mild [44]. 

In most cases, the healthcare provider will not be in a position to witness a seizure. Many patients (particularly those with complex partial [CP] or GTC seizures) are amnestic to the actual seizure event. Obtaining an accurate history and description of the ictal event (including time course) from a third party is important. 

The education of healthcare professionals, policy makers, students, and the public about genetics and the complex issues that result from genomic research. 

Obesity is a complex chronic condition with genetic, environmental, metabolic and psychological aspects. It has biochemical, biomechanical and sociological effects that lead to increased ill-health and early death and represents one of the biggest healthcare challenges of the 21st century. 

To fulfil this requirement, the concept of ecopharmacovigilance has been recently established [14], and due to the many facets of this complex issue, the communication between medical/healthcare communities, pharmaceutical industry, medicine and environmental regulators, academia and environmental science researchers is primordial. 

Acylcarnitine analysis using stable-isotope-labeled internal standards provides quantitative data for acylcarnitine species [14]. However, to provide meaningful results to referring healthcare providers, it is critical to complement analytical proficiency with in-depth interpretation of results, as is true for many other examples of complex metabolic profiles [39]. 

The current system is in crisis. The system has failed to address the needs of the developing world and it is in danger of failing to address the needs of the developed world too. But we know from the loM s report on the healthcare delivery system and from observations on the way complex adaptive systems behave that all the components of a system must share a goal in order to achieve it. So we know that reframing the obligations of one component of the system, the pharmaceuticals, will not be enough to achieve the outcomes we want. 

There is a complex web of interactions between traditional medicine, biodiversity conservation, protection of indigenous rights, encouraging research and development investment, improving access to medicines and enhancing healthcare. Placing tension at one point in that delicate web can dramatically alter the interactions and the outcomes of natural product research. 

The validation documentation set provided by a supplier of COTS will be standard rather than being tailored in advance with the users. Nevertheless, pharmaceutical and healthcare companies should map supplier documentation to validation requirements in an attempt to satisfy the latter. This mapping may be quite complex, and a direct correlation impossible. However, at a minimum the mapping should cover ... 

Pharmaceutical and healthcare companies shonld consider working with key individnal snppliers and industry groups to help suppliers develop electronic record/signatnre-compliant COTS products. Current versions of COTS prodncts need not be specifically cnstomized for nsers to provide full electronic record/signatnre fnnctionality the development risk with bespoke development must balance with the complexity and criticality of the change. It shonld be possible to compensate for the lack of key software fnnctionality by adding nser procednral controls. 

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