Health Designs

TOPI-CAT toxicology prediction tool Health Designs Inc. (HDI)... 

There are two commercially available expert systems that rely on a statistical approach TOPKAT, which was developed by Health Designs Inc. but is now owned by Accelrys [18], and CASE/MultiCASE, developed at Case Western University [31]. 

HDI Toxicology Newsletter (1987). HDI develops rabbit eye irritation model. No. 6 (Enslein, K., Ed.) Health Designs, Inc., Rochester, New York. 

Enslein, K., Blake, B. W., Tomb, M. E. and Borgstedt. H. H. (1986). In Vitro Toxicology 1, 33-44. TOPKAT Program, Health Designs Incorporated, 183 East Main St., Rochester, New York, USA. 

The example of the toxicity estimation using QSAR is based on the TOPKAT system developed by Health Designs, Inc., and is the computer program... 

Ketones as a group are considered narcotic. The primary hazard of the esters is polymerization. Many of them are flammable liquids and polymers. The DOT does list some ester compounds as Class 6.1 poisons and, again, these compounds have chlorine added, which accounts for their toxicity. For example, ethyl chloroformate is an ester that has an NFPA health designation of 4. Remember that too much of any chemical can be toxic, so too much of an anesthetic or a narcotic can be toxic. 

Ulrich, R.S., Zimring, C., Zhu, X. et al. (2008) A review of the research literature on evidence-based design. Center for Health Design, College of Architecture, Georgia Institute of Technology, United States. 

Buckle, R, Clarkson, P.J., Coleman, R., Lane, R., Stubbs, D., Ward, J., Jarrett, J. and Bound, J. 2003. Design for Patient Safety A System-wide Design-led Approach to Tackling Patient Safety in the NHS. London Department of Health/Design Council. 

Fig. 9.7. Computer screens from the TOPKAT program showing a prediction of toxicity for 4-chloro-/77-cresol against Fathead Minnow (figures kindiy suppiied by Health Designs Inc.).

Avoid bringing hazards into the workplace—by incorporating safety and health design and material specifications in procurement contracts for facilities, equipment, and materials. 

Environmental safety and health design features These have an impact on product design features and could become an integral part of the product to reduce the likelihood and consequence of propagation of hazards [1]. So, these are part of the product. 

Enslein K, Gombar VK, Shapiro D, Blake BW (1998) Prediction of rat oral LD50 values of chemicals by QSAR equations. TOPKAT Health Designs, Rochester, NY Enslein K, Knaak JB, Van Nostrand K, Susa R, Koestler D (2007) CYP3A4 hydroxylation kinetics QSAR models with application to PBPK modeling. J Comput Aided Mol Des. An internal document-Enslein Research, Inc., Rochester, NY. (submitted). 

X-ray crystallographic analysis Modeling software, AMBER, UniChem, VAMP, RS Discovery database system, products of CAChe Scientific, Health Designs (TOPKAT), IntelliGenetics, Genetics Computer Group (GCG)... 

KURT ENSLEIN, THOMAS M. TUZZEO, HAROLD H. BORGSTEDT, BENJAMIN W. BLAKE and JEFFREY B. HART Health Designs, Inc., 183 East Main Street,... 

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