Headache ciprofloxacin

Headache was recorded in 8% of patients taking ciprofloxacin and 9% taking ofloxacin during short-course treatment of urinary tract infections (18). Similar rates are reported for grepafloxacin (17). 

Nausea, diarrhea, headache, abdominal discomfort, ph oto sen sitivity, superi nfectio ns, hypersensitivity reactions me as ciprofloxacin... 

The ciprofloxacin I am taking gives me headaches. Is there anything I can do to help this ... 

If you don t have a history of headaches, then your headache may be related to the medicine. Changing the time of day that you take the ciprofloxacin or eating after you take the medicine may help. Pain relievers such as acetaminophen may help your headache. If your headache does not go aw ay, you should consult your doctor. 

Information on this interaction and its clinical relevance is limited. The author of the pharmacokinetic study suggests that, if the drugs need to be used together, the dosage of pentoxifylline should be halved. In the absence of other information, if a short-course of ciprofloxacin is required in a patient taking pentoxifylline, this may be a sensible precaution. Alternatively, because the increase in AUC was minor, it may be sufficient to recommend a reduction in pentoxifylline dose only in those who experience adverse effects (e.g. nausea, headache). Note that ciprofloxacin has been used to boost pentoxifylline levels in studies investigating the possible therapeutic value of pentoxifylline s ability to inhibit various cytokines. For example, ciprofloxacin 500 mg twice daily was used with pentoxifylline 800 mg three times daily for up to one year in patients with myelod-ysplastic syndrome. ... 

Because patients taking pentoxifylline and ciprofloxacin often complained of headache, the possibility of a pharmacokinetic interaction was studied in 6 healthy subjects. The study showed that ciprofloxacin 5(X) mg daily for 3 days increased the peak serum levels of a single 4(X)-mg dose of pentoxifylline by almost 60% (from 114.5 to 179.5 nanograms/mL), and increased the AUC by 15%. All 6 subjects complained of a frontal headache. ... 

Established interactions. Based on the results of two studies, on a scale of 100 to 0, the relative potencies of these quinolones as inhibitors of caffeine elimination have been determined as follows enoxacin 100, pipemidic acid 29, ciprofloxacin 11, norfloxacin 9 and ofloxacin 0. From further studies, clinafloxacin appears to be similar to enoxacin (profound effect), pefloxacin to norfloxacin (to which it is metabolised modest effect), and fleroxacin, lomefloxacin, rufloxacin, and trovafloxacin appear to behave like ofloxacin (no effect). Patients taking enoxacin might be expected to experience an increase in the effects of caffeine (such as headache, jitteriness, restlessness, insomnia) if, for example, they continue to drink their usual amounts of caffeine-containing drinks (tea, coffee, cola drinks, etc.). They should be warned to cut out or reduce their intake of caffeine if this occurs. The authors of one report suggest that patients with hepatic disorders, cardiac arrhythmias or latent epilepsy should avoid caffeine if they take enoxacin for one week or more. The effects of pipemidic acid arc less, and those of ciprofloxacin, norfloxacin and pefloxacin arc probably of little or no clinical importance. Fleroxacin, lomefloxacin, ofloxacin, rufloxacin, and trovafloxacin do not interact. 

Drug formulations Ciprofloxacin extended-release (Ciprofloxacin XR) 1000 mg/day has been compared with ciprofloxacin 500 mg bd in 103 and 109 patients respectively for complicated urinary tract infections there were single episodes of headache, glycosuria, erythema, and raised gamma-glutamyl transferase activity in the former [50 ]. 

A randomised, placebo-controlled trial using 500 mg ciprofloxacin twice daily for the prevention of postoperative recurrence of Crohn s disease did not show a benefit of the treatment over the disease. The following adverse events were listed diarrhoea, headache, sxm sensitivity, yeast infection, oral candidiasis, difficulty breathing, pharyngeal paraesthesia and tendonitis. Twenty-four percent of subjects (four cases) withdrew due to adverse events [23 ]. These are all expected side effects of ciprofloxacin. Similarly, use of ciprofloxacin 300 mg twice daily in febrile... 

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