Mild hypothermia head injury

Shiozaki T., Sugimoto H., Taneda M., et al. (1993) Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J. Neurosurg. 79, 363-368. 

Soukup J., Zauner A., Doppenberg E. M., et al. (2002) Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury the effect of mild hypothermia. Neurol. Res. 24, 161-168. 

Hypothermia in stroke and head-injured patients is started as soon as possible after injury, and continues for the duration selected by the investigator. Each patient undergoing treatment with mild hypothermia should be paralyzed and sedated to prevent discomfort and reduce shivering. Unfortunately, this can compromise accurate evaluation of the neurological status in patients with acute head injury or stroke. Therefore, continuous monitoring of ICP is important in these intensive care unit patients. Because these patients are paralyzed and sedated, continuous mechanical ventilation is also necessary. Neuromuscular blocking... 

Ishikawa K, Tanaka H, Takaoka M, et al. Granulocyte colony-stimulating factor ameliorates life-threatening infections after combined therapy with barbiturates and mild hypothermia in patients with severe head injuries. J Trauma 1999 46 999-1007. 

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