Head and neck squamous cell carcinoma HNSCC

Brun et at. [96] assessed the value of [ F]-FDG-PET in prediction of therapy outcome in 47 patients with locally advanced head and neck squamous cell carcinoma (HNSCC). As early as 5-10 days after initiation of radiotherapy, determination of the metabolic rate was correlated with 5-year survival. Patients with a metabolic rate lower than the median turned out to have a significantly higher 5-year survival (72% vs. 35%, p = 0.004), whereas determination of SUV showed no correlation at this time point. 

Karahatay, S., Thomas, K., Koybasi, S., Senkal, C.E., Elojeimy, S., Liu, X., Bielawski, J., Day, T.A., Gillespie, M.B., Sinha, D., Norris, J.S., Hannun, Y.A., and Ogretmen, B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC) attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett, 256, 2007, 101-111. 

Cetuximab is also FDA approved for the treatment of locally advanced and metastatic head and neck squamous cell carcinoma (HNSCC). In a phase III trial, patients with locally advanced HNSCC were randomized to radiation therapy with or without cetuximab. The addition of cetuximab provided a... 

CP carboplatin-paclitaxel 5-FU 5-fluorouracil HNSCC head and neck squamous cell carcinoma IFL irinotecan, 5-fluorouraciI, leucovorin N number of patients NR not reported CRC colorectal cancer NSCLC nonsmall cell lung cancer OS overall survival PFS progression-free survival RR response rate RT radiotherapy. 

Eriksen JG et al. (2005a) The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times. Radiother Oncol 76(2) 135-142 Eriksen JG, Steiniche T, Overgaard J (2005b) The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study. Radiother Oncol 74(2) 93-100... 

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