Hazardous substances reprotoxicity

The definition of hazardous in combination with substances follows the European Occupational Safety and Health legislation i.e. every substance that has been assigned a so-called H(azard)-statement. Carcinogenicity, Mutagenicity or Reprotoxicity (CMR) are reflected in specific H-statements, but many other types of toxicity exist. This approach should diminish the confusion that arises when hazardous is considered synonym with CMR or, in other situations, even with CMR plus some specific types of toxicity. Let alone if hazardous substances is considered synonym with the therapeutic class of antineoplastics. 

However, the use of the term hazardous substances with regard to pharmacy preparation and recraistitution, is often restricted to carcinogenic, mutagenic and reprotoxic substances. Radiopharmaceuticals and gene therapeutics may be counted under this term as well. The National Institute of Occupational Safety and Health of the US (NIOSH) however also counts substances with a high chronic toxic potential to hazardous substances , see further Sect. 26.3.3. 

So the term hazardous substances may have different notions. In this chapter the CLP definition is followed meaning that all substances are considered potentially hazardous. Carcinogenic, reprotoxic and mutagenic substances are either noted as such or as a group as CMR. Occupational safety and health care investigates all processes and all substances, to prevent health damage of workers. 

The National Institute for Occupational Safety and Health (NIOSH) of the United States describes in the section Determining whether a drug is hazardous how human and animal data on carcinogenicity, reprotoxicity and genotoxicity are interpreted for their list of hazardous substances [8]. 

Social mobilisation appears to be initiated by (i) the potential hazardous properties of a substance, regardless of exposure or (ii) the exposure of vulnerable groups (e.g., children or elderly) to a chemical, regardless of hazard. Reporting commonly used household products as containing potentially carcinogenic or potentially reprotoxic ... 

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