Hazard studies guideline documents

As the project progresses, more information is available therefore, the review technique used can be different at each stage of the project. The use of various hazard evaluation techniques, such as checklist analyses, relative rankings, what-if analyses, and hazard and operability studies, is documented in Guidelines for Hazard Evaluation Procedures Second Edition with Worked Examples (CCPS, 1992). The need to use more quantitative techniques for hazard evaluation may be identified during these reviews, and become an action item for the project team. 

Farber, T.M. (1987). Pesticide assessment guidelines, subdivision F, position document Selection of a maximum tolerated dose (MTD) in oncogenicity studies. Toxicology Branch, Hazard Evaluation Division, Office of Pesticides Programs, USEPA. NTIS PB88-116736. 

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