Harden, Sir Arthur

HARDEN. SIR ARTHUR (1865-1940). An English chemist who won the Nobel prize in chemistry in 1929 along with Hans von-Euler C helpin. He discovered fermentation enzy mes and demonstrated the structure of zymase, llis fermentation work proved how inorganic phosphates speeded the process. Bora in England, he received his doctorate in Germany. 

Harden, Sir Arthur (1865-1940) British chemist who shared the 1929 Nobel Prize in chemistry with Hans Euler-Chelpin for their classic work on fermentation enzymes. Harden proved that living organisms were not necessary for fermentation and that the process could be inhibited if a factor was removed by dialysis. This was the enzyme. He also found that during fermentation, inorganic phosphate esterified into organic forms. 

Sir Arthur Harden sent eight letters from British biochemists proposing more or less important modifications. 

In 1931 Otto Warburg discovered that the oxidation of glucose 6-phosphate in red blood cells required both an enzyme and a heat stable coenzyme, and he later referred to the latter as the Wasserstolfubertragendes Co-Ferment , i> to distinguish it from cozymase, the coenzyme of yeast fermentation, which had been discovered many years earlier by Sir Arthur Harden. He found that the functional group in both coenzymes was nicotinamide, which acted as acceptor for the protons removed from the substrate. In addition to nicotinamide, each coenzyme also contained one adenine and two ribosyl residues, but they differed in their phosphorus content. These observations led him to name the cozymase diphosphopyridine nucleotide (DPN), and the hydrogen-transferring coenzyme tri-phosphopyridine nucleotide (TPN). ... 

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