Haloperidol olanzapine

Ariplprazole Clozapine vr vcXyfo/ Haloperidol Olanzapine Quetta pine Risperidone j Ziprasidone ... 

Antidepressants tricyclics, mirtazepine, fluoxetine Antipsychotics clozapine, haloperidol, olanzapine, phenothiazines... 

A variety of relatively uncommon dermatological side effects have been noted to be associated with antipsychotic agents. These include maculopapular rashes, urticaria, and erythema multiforme (Arana, 2000). Photosensitivity and skin pigmentation can also occur during treatment with these drugs. Although skin pigmentation has been most frequently reported with chlorpromazine, this can occur with thioridazine and trifluoperazine (Harth and Rapoport, 1996). In addition, treatment-induced alopecia has been reported for haloperidol, olanzapine, and risperidone (Mercke et ah, 2000). 

Larmo I, de Nayer A, Windhager E, Lindenbauer B, Rittmannsberger H, Platz T, Jones AM, Altman C Spectrum Study Group. Efficacy and tolerability of quetiapine in patients with schizophrenia who switched from haloperidol, olanzapine or risperidone. Hum Psychopharmacol 2005 20 573-81. 

Note. None of these medications have FDA indication for the treatment of Alzheimer s disease. The literature and practice guidelines support the use of these medications for specific target symptoms. The FDA has issued a black box warning regarding the use of certain antipsychotic medications in the elderly, especially haloperidol, olanzapine, and risperidone. The warning notes that the use of these drugs is associated with an increase in death rates when used by the elderly patients with dementia. 

CHLORPROMAZINE, CLOZAPINE, HALOPERIDOL, OLANZAPINE BUPROPION T plasma concentrations of these drugs with risk of toxic/adverse effects Smoking induces mainly CYP1A2 and CYP2E1. Thus de-induction takes place following cessation of smoking Be aware and watch for early features of toxicity. Consider reducing the dose... 

CIMETIDINE ANTIPSYCHOTICS -CHLORPROMAZINE, CLOZAPINE, HALOPERIDOL, OLANZAPINE, PERPHENAZINE, RISPERIDONE, SERTINDOLE, THIORIDAZINE, ZUCLOPENTHIXOL T plasma concentrations of these antipsychotics, with risk of associated adverse effects - Drugs Acting on the Nervous System, Antipsychotics Cimetidine is an inhibitor of CYP3A4 (sertindole, haloperidol, risperidone) CYP2D6 (chlorpromazine, risperidone, zudopenthixol, thioridazine, perphenazine) and CYP1A2 (clozapine, olanzapine, sertindole, haloperidol) Avoid concomitant use. Choose alternative acid suppression... 

Perez-Iglesias R, Crespo-Facorro B, Amado JA, et al, A 12-week randomized clinical trial to evaluate metabolic changes in drug-naive, first-episode psychosis patients treated with haloperidol, olanzapine, or risperidone, J Clin Psychiatry 2007 68(l 1) 1733 0,... 

Fluvoxamine (Luvox) Nefazodone (Serzone) Paroxetine (Paxil) CLOZAPINE, THIORIDAZINE, HALOPERIDOL, OLANZAPINE, THIOTHIXENE PHENOTHIAZINES, Risperidone, Aripiprazole Clozapine, Quetiapine, Ziprasidone QUETIAPINE, Clozapine, Ziprasidone ... 

CLOZAPINE, HALOPERIDOL, OLANZAPINE CNS STIMULANTS-MODAEINIL May cause X plasma concentrations of these substrates if CYPl A2 is the predominant metabolic pathway and alternative metabolic pathways are either genetically deficient or affected Modafinil is a moderate inducer of CYPl A2 in a concentration-dependent manner Be aware. Patients who are using oestrogen-containing contraceptives should be warned to use alternative forms of contraception during and for at least 1 month after cessation of modafinil... 

Activated charcoal causes a fall in olanzapine levels and venlafax-ine moderately raise olanzapine levels. Additive dopaminergic effects have been seen in one patient taking olanzapine and haloperidoL Olanzapine appears not to interact to a clinically relevant extent with aluminium/magnesium hydroxide antacids, ci-metidine or diazepam. However, excessive sedation and hypotension may occur with parenteral benzodiazepines and intramuscular olanzapine. 

The effects of antipsychotic drugs (haloperidol, olanzapine, and risperidone) on peptides involved in energy balance (insulin. 

Antidepressants including tricyclics, serotonin reuptake inhibitors, and monoamine oxidase inhibitors Antipsychotics drugs such as phenothiazines, haloperidol, olanzapine, or clozapine Other analgesics and anti-inflammatory agents... 

Consider adding an antipsychotic (e.g. haloperidol/olanzapine) if distressing psychotic symptoms persist despite increasing benzodiazepines. 

A comprehensive review article on tiie treatment of Hxmtington s disease evaluated the data on different antipsy-chotics (aripiprazole, clozapine, haloperidol, olanzapine, pimozide, risperidone, quetiapine, ziprasidone) and summarised the main side effects and drug interactions [25 ]. 

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