Haloperidol endocrine

CJ-Receptors are localized ia the brain stem and limbic stmcture, regions associated with endocrine function (76). In the periphery, CJ-receptors are found in the Hver, heart, ileum, vas deferens, and on lymphocytes and thymocytes. Although there is insufficient evidence to clearly define the functional role of CNS CJ-sites, based on the effects of PCP and the interaction of haloperidol with CJ-sites, CJ-receptor ligands may be antipsychotics or used for the treatment of substance abuse. Several CJ-receptor ligands have shown neuroprotective effects in vivo. Ifenprodil (315) and CNS 1102 (316) are being developed for treatment of stroke (Table 18). 

Brown AS, GershonS Dopamine and depression. J Neural Transm 91 75-109, 1993 Brown D, Silverstone T, Cookson J Carbamazepine compared to haloperidol in acute mania. Int Clin Psychopharmacol 4 229-238, 1989 Brown CM Endocrine aspects of psychosocial dwarfism, in Hormones, Behavior, and Psychopathology. Edited by Sachar E. New York, Raven, 1975 Brown GR, RundeU JR A prospective study of psychiatric aspects of early HIV disease in women. Gen Hosp Psychiatry 15 139-147, 1993 Brown GW, Harris TO Aetiology of anxiety and depressive disorders in an inner-city population, 1 early adversity. Psychol Med 23 143-154, 1993 Brown GW, Harris T, Copeland JR Depression and loss. Br J Psychiatry 130 1-18, 1977... 

The results of 11 studies in 1933 patients with schizophrenia, who were randomly assigned to amisulpride (n = 1247), haloperidol (n = 309), risperidone (n = 113), flupenthixol (n = 62), or placebo (n = 202) have been reviewed (45). Extrapyramidal signs occurred in 15% of those given amisulpride (n = 579), 12% of those given risperidone (n = 113), and 31% of those given haloperidol (n = 214). In contrast, endocrine disorders were more frequent with amisulpride (4%) and risperidone (6%) than with haloperidol (1%). In a subgroup of patients with predominant negative schizophrenia who had at... 

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