Halogenated lipids lipidic targets

INTRODUCTION PEROXIDASE PRODUCTS TARGETING THE PHOSPHOLIPID MILIEU OF MEMBRANES AND THE LIBERATION OF HALOGENATED LIPIDS... 

FIGURE 4.1 Lipidic targets of reactive halogenating species produced by peroxidases. Membrane-associated plasmenylethanolamine (16 0-18 1 [ of carbons of double bonds in the sn-l-sn-2 positions of the glycerol backbone]) contains three reactive sites for reactive halogenating species to target as shaded in gray. 

In this chapter these individual lipid targets, their halogenated products and the biochemical and biological consequences of the liberated halogenated products will be reviewed. 

While previous studies have focused on MPO in cardiovascular disease, it is important to consider the role of monocytes, macrophages, eosinophils, and neutrophils as mediators of innate immunity, and as important responsive cells in inflammation. The role of MPO and EPO and their hypohalous acids targeting lipids to generate novel halogenated lipids is relatively unexplored, and should be thoroughly examined, in diseases including pancreatitis, asthma, renal glomerular, and tubular disease. 

Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids... 

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