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Organometallic compounds halides

In Grignard reactions, Mg(0) metal reacts with organic halides of. sp carbons (alkyl halides) more easily than halides of sp carbons (aryl and alkenyl halides). On the other hand. Pd(0) complexes react more easily with halides of carbons. In other words, alkenyl and aryl halides undergo facile oxidative additions to Pd(0) to form complexes 1 which have a Pd—C tr-bond as an initial step. Then mainly two transformations of these intermediate complexes are possible insertion and transmetallation. Unsaturated compounds such as alkenes. conjugated dienes, alkynes, and CO insert into the Pd—C bond. The final step of the reactions is reductive elimination or elimination of /J-hydro-gen. At the same time, the Pd(0) catalytic species is regenerated to start a new catalytic cycle. The transmetallation takes place with organometallic compounds of Li, Mg, Zn, B, Al, Sn, Si, Hg, etc., and the reaction terminates by reductive elimination. [Pg.125]

Formation of ketones. Ketones can be prepared by the carbonylation of halides and pseudo-halides in the presence of various organometallic compounds of Zn, B, Al, Sn, Si, and Hg, and other carbon nucleophiles, which attack acylpalladium intermediates (transmetallation and reductive elimination). [Pg.200]

The properties of organometallic compounds are much different from those of the other classes we have studied to this point Most important many organometallic com pounds are powerful sources of nucleophilic carbon something that makes them espe cially valuable to the synthetic organic chemist For example the preparation of alkynes by the reaction of sodium acetylide with alkyl halides (Section 9 6) depends on the presence of a negatively charged nucleophilic carbon m acetylide ion... [Pg.587]

Organometallic compounds of copper were known for a long time before their versatil ity in synthetic organic chemistry was fully appreciated The most useful ones are the lithium dialkylcuprates which result when a copper(I) halide reacts with two equivalents of an alkyllithium in diethyl ether or tetrahydrofuran... [Pg.602]

Grignard reagents react with ethylene oxide to yield primary alcohols containing two more carbon atoms than the alkyl halide from which the organometallic compound was prepared... [Pg.632]

The fundamental Ziegler-Natta recipe consists of two components the halide or some other compound of a transition metal from among the group IVB to VIIIB elements and an organometallic compound of a representative metal from groups lA to IIIA. Some of the transition metal compounds that have been... [Pg.488]

The bimetallic mechanism is illustrated in Fig. 7.13b the bimetallic active center is the distinguishing feature of this mechanism. The precise distribution of halides and alkyls is not spelled out because of the exchanges described by reaction (7.Q). An alkyl bridge is assumed based on observations of other organometallic compounds. The pi coordination of the olefin with the titanium is followed by insertion of the monomer into the bridge to propagate the reaction. [Pg.493]

Benzyne can also be generated from o-dihaloaromatics. Reaction of lithium amalgam or magnesium results in formation of a transient organometallic compound that decomposes with elimination of lithium halide. l-Bromo-2-fluorobenzene is the usual starting material in this procedure. [Pg.596]

Before we describe the applications of organometallic reagents to organic synthesis, let us examine their preparation. Organolithium compounds and other Group I organometallic compounds are prepared by the reaction of an alkyl halide with the appropriate metal. [Pg.589]

Grignard reagents are a very important class of organometallic compounds. For their preparation an alkyl halide or aryl halide 5 is reacted with magnesium metal. The formation of the organometallic species takes place at the metal surface by transfer of an electron from magnesium to a halide molecule, an alkyl or aryl radical species 6 respectively is formed. Whether the intermediate radical species stays adsorbed at the metal surface (the A-modelf, or desorbs into solution (the D-model), still is in debate ... [Pg.142]

Mechanistically the reaction can be divided into two steps. Initially the alkyl halide 1 reacts with sodium to give an organometallic species 3, that can be isolated in many cases. In a second step the carbanionic R of the organometallic compound 3 acts as nucleophile in a substitution reaction with alkyl halide 1 to replace the halide ... [Pg.304]

Many other kinds of organometallic compounds can be prepared in a manner similar to that of Grignard reagents. For instance, alkyllithium reagents, RLi, can be prepared by the reaction of an alkyl halide with lithium metal. Alkyllithiums are both nucleophiles and strong bases, and their chemistry is similar in many respects to that of alkylmagnesium halides. [Pg.346]

E. Reacticms Involving Organometallic Compounds 1. Reaction of lithium alkyls with organic halides... [Pg.110]

When the antitumor activity of cisplatin was discovered, several research groups started to investigate the possible therapeutic applications of other metal-based, often organometallic, compounds. The organotin(lV) compounds that were first tested were those that were available or easily synthesized, like tri- or diorganotin(rV) halides. [Pg.423]

It might be mentioned that matters are much simpler for organometallic compounds with less-polar bonds. Thus Et2Hg and EtHgCl are both definite compounds, the former is a liquid and the latter is a solid. Organocalcium reagents are also known, and they are formed from alkyl halides via a single electron transfer (SET) mechanism with free-radical intermediates. "... [Pg.237]

It seems likely that the mechanism of the Wurtz reaction consists of two basic steps. The first is halogen-metal exchange to give an organometallic compound (RX -(- M —+ RM), which in many cases can be isolated (12-36). Following this, the organometallic compound reacts with a second molecule of alkyl halide (RX + RM —> RR). This reaction and its mechanism are considered in the next section (10-94). [Pg.536]

The Conversion of Acyl Halides to Ketones With Organometallic Compounds ... [Pg.566]


See other pages where Organometallic compounds halides is mentioned: [Pg.744]    [Pg.744]    [Pg.5]    [Pg.791]    [Pg.8]    [Pg.434]    [Pg.238]    [Pg.99]    [Pg.2]    [Pg.179]    [Pg.567]    [Pg.794]   
See also in sourсe #XX -- [ Pg.931 , Pg.932 , Pg.1167 , Pg.1168 , Pg.1169 , Pg.1170 , Pg.1171 ]

See also in sourсe #XX -- [ Pg.931 , Pg.932 , Pg.1167 , Pg.1168 , Pg.1169 , Pg.1170 , Pg.1171 ]




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Alkenyl halides, coupling with metals organometallic compounds from

Aryl halides organometallic compound cross-coupling

Coupling of alkyl halides with organometallic compounds

Cross-coupling halides with organometallic compounds

Halides compounds

Halides organometallic

Halides, alkyl from organometallic compounds

Halides, aryl from organometallic compounds

Halides, vinyl from organometallic compounds

Mixed halides organometallic compounds

Organometallic compound, coupling with alkyl halide

Organometallic compounds acyl halide coupling

Organometallic compounds alkyl halides

Organometallic compounds reaction with 1 -alkynyl halides

Organometallic compounds reaction with alkyl halides

Organometallic compounds with acyl halides

Organometallic compounds with alkyl halides

Organometallic compounds with aryl halides

Organometallic compounds with halides

Organometallic compounds with unsaturated halides

Organometallic compounds, 1,4-addition metals with halides

Organometallic compounds, also from alkyl halides

Organometallic compounds, also from aryl halides

Organometallic compounds, also from halides

Reactions of organometallic compounds with metal halides

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