Haemoglobin effect

Exposure ppm Probable concentration of CO in blood after 1 hr exposure (carboxy haemoglobin) Effect... 

Fig. 12. Effect of the degree of ionization of micro-disperse carboxylic CP on binding of haemoglobin 1) AA-EDMA (2.5 mol%) 2) M A-EDM A (2.5 mol%) 3) MA-EDMA (2.5 mol%)gr. m — quantity of Hb (g) bonded by crosslinked copolymers (g)...

Haemoglobin-derived haem iron has multiple pro-inflammatory effects resulting from its ability to initiate decomposition of lipid hydroperoxides from PUFAs. In... 

Pre-approval safety and efficacy clinical studies involved product administration to 2500 adults with either type-1 or -2 diabetes. The primary efficacy parameter measured was glycaemic control (as measured by the reduction from baseline in haemoglobin Ale). Hypoglycaemia was the most commonly reported adverse effect. Trials also showed a greater decline in pulmonary function in the Exubera group, and product should not be administered to patients with underlying lung disease, or to smokers. Exubera was developed by Nektar Inc. and is marketed under licence by Pfizer. 

Another, and more acute, trigger to the release of oxygen from haemoglobin is the pH of the blood surrounding the red cell. Protons arising from metabolic activity of tissues cause a right-shift in the position of the ODC and oxygen is released when the pH falls. This phenomenon is called the Bohr effect. 

Partial digestion of human haemoglobin by carbox rpeptidases A and B has shown that chemical modifications to the -chains are more effective in destroying haem-haem interaction than those to the a-chains while modifications to either chain decrease the magnitude of the Bohr effect. The C-terminal sequences of the two types of chain of human haemoglobin are as follows ... 

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