Gustatory receptor genes

Ueno K., Ohta M., Morita EL, Mikuni Y., Nakajima S., Yamamoto K. and Isono K. (2001) Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr. Biol. 11, 1451-1455. 

At present, the functional architecture of gustatory receptor gene expression, in particular for sweet and bitter, is being unravelled however, the functional configuration of these receptors as monomer, dimers or oligomers is not clear, and neither are their downstream intracellular signalling cascades, the transmitter used by their host sensory neurons and the precise connectivity of these cells to second-order intemeurons. 

Drosophila gustatory receptor (GR) genes a gene family that subserves both gustatory and olfactory modalities... 

Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W (2007) Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci 27 12630-12640 Behrens M, Meyerhof W (2006) Bitter taste receptors and human bitter taste perception. Cell Mol Life Sci 63 1501-1509... 

Smadja C, Shi P, Butlin RK, Robertson HM. Large gene family expansion and adaptive evolution for odorant and gustatory receptors in the pea aphid, Ac5Uthosiphon pisum. Mol Biol Evol. 2009 26 2073-86. 

Scott K., Brady J. R., Cravchick A., Morozov P., Rzhetsky A., Zuker C. and Axel R. (2001) A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell 104, 661-673. 

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