Guillain-Barre syndrome molecular mimicry

Sheikh KA, Nachamkin I, Ho TW, WiUison HJ, Veitch J, Ung H, Nicholson M, Li CY, Wu HS, Shen BQ, Cornblath DR, Asbury AK, McKhann GM, Griffin JW (1998) Campylobacter jejuni Upo-polysaccharides in Guillain-Barre syndrome Molecular mimicry and host susceptibility. Neurology 51 371-378. 

Yuki, N., Handa, S., Taki, T., Kasama, T., Takahashi, M., Saito, K., and Miyatake, T., 1992, Cross-reactive antigen between nervous tissue and a bacterium elicits Guillain-Barre syndrome. Molecular mimicry between ganglioside GMl and liposaccharide from Penner s serotype 19 of Campylobacter jejuni, Biomed. Res. 13 451-453. 

It is known as Guillain-Barre syndrome. It is named after the French neurologists G. Guillain and A. Barre. Guillain-Barre syndrome is, therefore, an example of molecular mimicry. 

Ang, C.W., Jacobs, B.C., Laman, J.D. The Guillain-Barre syndrome a tme case of molecular mimicry. Trends Immunol 25 (2004) 61-66. 

Moran, A.P., Prendergast, M.M. Molecular mimicry in Campylobacter jejuni lipopolysaccharides and the development of Guillain-Barre syndrome. J Infect Dis 178 (1998) 1549-1550. 

Oomes PG, Jacobs BC, Hazenberg MPH, Banffer JRJ, van der Meche FGA (1995) Anti-GMl IgG antibodies and Campylobacter jejuni bacteria in Guillain-Barre syndrome Evidence of molecular mimicry. Ann Neurol 38 170-175. 

Yu RK, Usuki S, and Ariga T (2006) Ganglioside molecular mimicry and its pafliologi-cal roles in Guillain-Barre syndrome and related diseases. Infect Immun 74 6517—6527... 

The structure of the core ohgosaccharides of Campylobacter jejuni 02 LPS was found to contain 3-deoxy-D-m nno-octulosonic acid (Kdo), L-glycero-D-manno-heptose (LD-Hep), D-Gal, D-Glc and phosphoethanolamine based on H, and P NMR. Molecular mimicry in C. jejuni LPS has been implicated in the pathogenesis of Guillain-Barre syndrome by inducing antibodies to human gangliosides. 

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