Guanine Nucleotide Exchange Factors GEFs in Signal Transduction via Ras Proteins

5 Guanine Nucleotide Exchange Factors (GEFs) in Signal Transduction via Ras Proteins 

Ras protein is a central switching station in intracellular signal transduction, which receives, modulates and passes signals on. The Ras protein receives, in particular, signals promoting growth and differentiation, which start from activated receptor tyro- 

In addition to growth hormone signals, other signals such as Ca signals are also processed by the Ras switching station. 

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The transition from inactive GDP state to active GTP state may be accelerated by proteins that cause the boimd GDP to dissociate. The guanine nucleotide exchange factors (GEF) play an essential role in signal transduction via Ras proteins. Loss of exchange activity by mutation of the exchange proteins has the same effect in lower organisms as loss of the Ras gene. 

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