Guanidine carbonate

The 6-methyl derivative (98, R = Me) was an important intermediate in the synthesis of analogs (e.g., 183) of folic acid. Korte has shown that 2-aminopyrido[3,2-aminopicolinic acid and that treatment of the same acid with ammonium thiocyanate or potassium cyanate yields the thioureido and ureido derivatives (100, X = S and X = 0). In contrast to the pyrido[2,3-d]pyrimidine system bsoth of these compounds could be cyclized by heat and the latter (100, X = O) is a likely intermediate in the synthesis of the dione (98) by the fusion with urea. 

Amino-5-methoxy pyrimidine is obtained having a melting point of about 300°C by condensation of methoxymalonic acid ester with guanidine carbonate in the presence of sodium ethylate. The resultant reaction product is then converted to 2-amino-5-methoxy-4,6-di-chloropyrimidine (melting point 216°C to 217°C) by heating this reaction product with phosphorus oxychloride. The dichloro compound is then suspended in water with zinc dust and... 

Both these materials are available commercially as powders and in impregnated wrapping papers and bags. Various modified inhibitors are also available, containing mixtures of the two, or more alkaline materials such as guanidine carbonate. Other proprietary inhibitors contain volatile amines, e.g. morpholine, combined with solution inhibitors. Certain solution inhibitors have been reported to act to some extent as volatile inhibitors. 

Robenidine hydrochloride labeled with carbon-14 in the amino guanidine carbon atom had a specific activity of 18.61 pCi/mg. 

Condensation of guanidine carbonate and acetylacetone yields the required 2-amino-4,6-dimethyIpyrimidine (Ref. 6) for sulfo-meturon methyl (Figure 6). 

Guanidine carbonate has also been combined with unsaturated 2-hydroxymethyl ketones 882 to give 2-amino-5,6-dihydroquinazolines 883, which were subsequently dehydrogenated to the fully conjugated 2-aminoquinazolines <2002TL3295>. 

The diazaboroloimidazoles 195 have been formed in modest yields by reaction between 1,2-dicarbonyl compounds, amidine salts 196 and guanidine carbonate salt, and diphenylboronic anhydride <1988CB1865>. A parallel reaction... 

Cycloalkane ring-fused 2,4-diaminopyrido[2,3-, pyrimidine 580 was obtained by direct treatment of sulfone 579 with guanidine carbonate in boiling diphenyl ether. Sulfoxide 579 was prepared by perbenzoic acid oxidation of the methylthio derivative <1994T199>. 

OB —42.1% crysts, mp 166—7°. Prepd by treating guanidine carbonate in aq ale with ethyl dinitrocyanoacetate at RT. Proposed as pro-pint ingredient... 

N 54.08%, OB —37.7% yel crysts, rap 164—4.5° (dec). Prepd by treating guanidine carbonate with 5-dinitromethyltetrazole. Its expl props were not investigated... 

N 51.40%, OB -36.7% It yel crysts, rap 225-8° (de c). Prepd by treating guanidine carbonate with 3,5 dinitro-as-4H-triazole in acet. The salt exhibits an impact sensitivity (2kg weight) of over 320cm, and is suggested for use as a press-loaded expl... 

According to equation (19) decomposition also occurs on boiling nitroguanidine in an aqueous solution of ammonium carbonate, with liberation of nitrous oxide and ammonia. The latter combines with the cyanamide also resulting from reaction (19) and guanidine carbonate is formed in almost quantitative yield. 

CH,NaO, mw 189.148, N 66.65% was obtained in the form of wh platelets(v/hich melted after purification at 225—226°) from guanidine carbonate, AcOH and nitramino-guanidine as described in Ref 2,p 2328... 

Guanidine Azidodithiocarbonate, HNC(NH2)2 HSCSNj, mw 178.25, N 47.15% col prisms, mp 88-90° (dec) readily sol in w or acet, sol in ale and almost insol in eth. It was prepd by interacting aq guanidine carbonate with freshly prepd solid azidodithiocarbonic acid or by reacting aq guanidine azide, HNC(NHa) -HNS, with purified CSa... 

As a 1,2-diketone, 4,7-phenanthroline-5,6-dione reacts readily with ethylenediamine258 and 5,6-diamino-4,7-phenanthroline266 to give pyrazine derivatives. Several related condensations have also been reported.258,267,268 It also condenses with enamines,269 trialkyl and dialkyl phosphites,262 and guanidine carbonate.270... 

Preparation of Guanidine Carbonate from Nitrogvanidine. Two hundred and eight grams of nitroguanidine, 300 grams of ammonium carbonate, and 1 liter of water are heated together in a 2-liter flask in the... 

Water, strontium hydroxide, glycerin, cetearyl alcohol, guanidine carbonate, thiolactic acid, CETEARETH-33, silica, titanium dioxide, BHA, EDTA, parfum, potassium hydroxide and squalane. 

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