Guanabenz

Chemical Name 2-[(2,6-Dichlorophenyl)methylene] hydrazinecarboximidamide Common Name -Structural Formula  

A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off MP 225°C to 227°C. 

Molecular formula C8H8CI2N4 Molecular weight 231.09 CAS Registry No 5051-62-7 Merck index 13,4574 

Sample preparation Mix 2 mL serum with 10 irL 10 (xg/mL IS in MeOH, add 200 jxL concentrated ammonium hydroxide, add 5 mL dichloromethane, shake on a reciprocating shaker for 30 min, centrifuge at 730 g for 20 min. (If excessive emulsion is present, mix by inversion and centrifuge again.). Evaporate the organic layer to dryness in a silanized glass tube under a stream of nitrogen below 40°, reconstitute the residue with 80 pL mobile phase, vortex, inject a 25 pL aliquot. 

Mobile phase Gradient. MeCN water formic acid 5 95 0.05 for 1 min, to 90 10 0.05 over 4 min, maintain at 90 10 0.05 for 5 min, return to initial conditions over 0.5 min, re-equilibrate for 4.5 min. 

Detector MS, Micromass Quattro II, positive ion mode, collision gas argon 3 pbar, photomultiplier 750-800 V, source cone 26 V, coUision energy — 23 1V, capiUaiy - -3.1 kV, HV lens 520 V, source 120°, m/z 231-172 

Harkins, J.D. Dirikolu, L. Lehner, A.F. Hughes, C. Schroedter, D. Mayer, B. Bratton, C. P4sher, M.V. Tobin, T. The detection and biotransformation of guanabenz in horses a preliminary report, Vet.Ther., 2003,4, 197-209. 

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Antiadrenergic drags (centrally acting)—for example, guanabenz (Wytensin) and guanfacine (Tenex)... 

CH6N4 79-17-4) see Ambazone Lamotrigine aminoguanidine carbonate (C2HSN4O3 2200-97-7) see Guanabenz... 

Central a2-Agonists Methyl dopa Clonidine (Catapres) Guanabenz Guanfacine (Tenex) Guanadrel No recommendations at this time Transient sedation initially First-line in pregnancy (methyldopa)... 

Also limited by their tendency to cause orthostasis, sedation, dry mouth, and vision disturbances, clonidine, methyldopa, and guanabenz represent rare choices in contemporary treatment... 

Clonidine, guanabenz, guanfacine, and methyldopa lower BP primarily by stimulating a2-adrenergic receptors in the brain, which reduces sympathetic outflow from the vasomotor center and increases vagal tone. Stimulation of presynaptic oq-receptors peripherally may contribute to the reduction in sympathetic tone. Consequently, there may be decreases in heart rate, cardiac output, total peripheral resistance, plasma renin activity, and baroreceptor reflexes. 

Any broad-spectrum antibiotic Antihypertensives Reserpine Guanethidine Methyldopa Guanabenz Guanadrel... 

Inability to gain acceptance on the U.S. market has not discouraged all efforts in this field and three other clinically effective drugs have been studied extensively, namely guanadrel (Upjohn, LVIII), guanabenz (Wyeth, LIX) and guancydine (Lederle LX). 

Guanabenz Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine [1-3],... 

Guanabenz is an a2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output. 

Guanidine operates exactly by the same mechanism as clonidine and guanabenz, and it is used for the same indications. A synonym of this drug is estulic. 

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