Guanabenz adverse effects

Guanabenz (Wytensin, others) is a centrally acting tt2 agonist that decreases BP by a mechanism similar to those of clonidine and gnanfacine. Guanabenz has a half-life of 4 to 6 hours and is extensively metabolized by the liver. Dosage adjustment may be necessary in patients with hepatic cirrhosis. The adverse effects caused by guanabenz (e.g., dry mouth and sedation) are similar to those seen with clonidine. 

Overall, the frequency of adverse effects produced by guanabenz is similar to that produced by cionidine and the other Q2-adrenergic agonists, but the incidence is lower. As with the other centrally active sympatholytics (e.g., cionidine), abrupt withdrawal of guanabenz may result in rebound hypertension, but the withdrawal syndrome symptoms appear to be less severe. 

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