GSK-3p glycogen synthase kinase

ACPD 1 -Aminocyclopentyl-1,3-dicarboxylate GSK-3P Glycogen synthase kinase 3p... 

Ginsenoside Rd, one of the principal active ingredients of Pcmax notoginseng, inhibits okadaic acid-induced tau phosphorylation in vivo and in vitro, inhibits tau phosphorylation at multiple sites in Ap-treated cultured cortical neurons, reduces Ap-induced increased expression of glycogen synthase kinase 3beta (GSK-3P), and enhances the activity of protein phosphatase 2A (PP-2A), a key phosphatase involved in tau dephosphorylation [273],... 

Scopolamine causes spatial learning and memory deficits that involved activation of glycogen synthase kinase-3 3 (GSK-3P) and impairments of dendrite arborization and spine formation/ maturation associated with alterations of AMPAR, Homerl, and CREB. Pretreatment by intraperitoneal injection of lithium, an inhibitor of GSK-3, for 1 week prevented the synaptic changes and the learning and memory deficits induced by scopolamine. Lithium treatment also activated cholineacetyltransferase and inhibited acetylcholinesterase, which might have also contributed to the improved memory [531],... 

Lithium is thought to act by blocking the fnnction of an enzyme called glycogen synthase kinase-3 (GSK-3(3) in the brain. Among other snbstances fonnd to block GSK-3p elsewhere in the body, lithinm salts are the only capable to get into the brain and then to combat bipolar disorder. Alan Kozikowski (University of Ilhnois in Chicago) took a directed, rational approach showing that newly discovered compounds called (3-(benzofnran-3-yl)-4-indol-3-yl) maleimides) are potent and relatively selective GSK-3 3 inhibitors. ... 

The T-protein is represented in neurons under normal conditimis. It is involved in the incorporation of tubulin into microtubules, stabilizing them, and affecting transport in axons [14]. Intracellular NFTs, consisting of paired helical fibers of paired helical filaments, arise within the course of AD. The main component of these fibers is hyperphosphorylated x-protein [15] that disrupts the formation and structure of tubulin and induces destabilization [16]. The influence of cyclin-dependent kinase 5 (CDK5) and glycogen synthase kinase 3p (GSK-3p) is a significant factor of hyperphosphorylation [17]. Recent... 

Lin et al. [17] Colon cancer Suppress MMP-7 expression and leptin-mediated cell invasion Lycopene could effectively inhibit the phosphorylation of Akt, glycogen synthase kinase-3p (GSK-SP), and ERK 1/2 proteins in human colon cancer HT-29 cells... 

Increased phosphorylation of neuronal APPP on Thr-668 has been demonstrated in Alzheimer disease brain and in brains of Alzheimer mouse models, and it was considered to be detrimental by increasing generation of Ap and inducing tau phosphorylation [34, 86, 87], Active glycogen synthase kinase 3P (GSK-3P) was proposed to have an important role in Alzheimer disease pathogenesis because it was shown to modulate both phosphorylation of tau, and of Appp on Thr-668 [88]. GSK-3P has been considered a link between Appp and phosphorylation of tau [89]. 

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