Grubbs, Nobel prize

The introduction of molybdenum by R. Schrock (Nobel Prize, 2005) and ruthenium catalyst systems by R. Grubbs (Nobel Prize, 2005), especially the commercially available Grubbs catalysP [bis(tricyclohexylphosphine)benzylidene ruthenium(IV) dichloride]. A, and its second-generation variant, B, shown below, " has led to many RCM applications in organic synthesis. ... 

Since the first reports on olefin metathesis in the 1960s [88, 89], this elementary C-C bond forming reaction has sparked an enormous activity in organometalhc research, culminating in the award of the Nobel Prize to Yves Chauvin, Richard Schrock and Robert Grubbs in 2005. 

Who shared the 2005 Nobel Prize in Chemistry with R.H. Grubbs and Y. Chauvin. 

Metal-catalyzed olefin metathesis had an enormous impact on organic synthesis in general. Extensive research on mechanistic aspects (3,4) and the development of catalysts has been performed, which culminated in the award of the Nobel Prize for Chemistry in 2005 to Chauvin, Grubbs and Schrock. 

Transition-metal-catalysed metathesis of alkenes (Scheme 1.12) is more removed from conventional organic chemistry than the above Michael-like reaction, and its investigation has been a major challenge (see Chapter 12). The novelty and enormous value of these reactions have been recognised by the award of the 2005 Nobel Prize for Chemistry to Chauvin, Schrock and Grubbs for their seminal investigations in this area [28]. 

The 2005 Nobel Prize in Chemistry was awarded to Yves Chauvin (French Petroleum Institute), Robert Grubbs (Caltech), and Richard Schrock (MIT) for developing effective ways to induce alkenes to undergo metathesis. 

Grubbs (Fig. 8.7) was named Victor and Elizabeth Atkins Professor of Chemistry at Caltech in 1990 and, apart from the Nobel Prize, has received a long list of awards including the ACS Award in Organometallic Chemistry, the ACS Award in Polymer Chemistry, the Benjamin Franklin Medal in Chemistry, the ACS Herbert C. Brown Award for Creative Research in Synthetic... 

Fig. 8.7 Robert H. Grubbs at the time when he received the Nobel Prize (photo by courtesy of R.H.G. reproduced with permission from Caltech)...

R. H. Grubbs, Autobiography, in Les Prix Nobel, The Nobel Prizes 2005 (Ed. K. Grandin, [Nobel Foundation], Stockholm, 2006). 

The word metathesis is derived from the Greek words meta (change) and fhes/s (position). The 2005 Nobel Prize in Chemistry was awarded to Robert Grubbs of the California Institute of Technology,... 

Grubbs, Robert H. (1942- ). An American bom in Calvert City, Kentucky who won the Nobel Prize for chemistry in 2005 for his pioneering work concerning the development of the metathesis method in organic synthesis. Grubbs was awarded a B.S. and M.S. in chemistry from the University of Florida, and obtained his Ph.D. at Columbia University. He is the Victor and Elizabeth Atkins Professor of Chemistry at the California Institute of Technology and is a member of the National Academy of Sciences. 

Already in this century, six chemists have received the Nobel Prize for seminal work in organometallic chemistry. Noyori, Knowles, and Sharpless became Nobel Laureates in 2001 as a result of their work on the use of organometallic complexes to catalyze asymmetric hydrogenation and oxidation reactions of organic compounds. More details of this work will appear in Chapter 12. Just four years later, Chauvin, Grubbs, and Schrock were honored... 

In 2005, Yves Chauvin, Robert Grubbs, and Richard Schrock were awarded the Nobel Prize in Chemistry for their fundamental studies on the mechanism and applications of metathesis. We will encounter much of their work in the following sections. 

Richard Schrock(MIT, USA) and Robert Grubbs (CalTech, USA) received 2005 Nobel prize for their work on the subject. Metathesis is the exchange of the termination between two alkenes... 

Ian C. Stewart is a chemist for a petrochemical company. He formerly worked with Nobel Prize-winning chemist Robert H. Grubbs and is the recipient of several fellowships. Justin P. Lomont is a National Science Foundation Graduate Research Fellow whose doctoral research at the University of California, Berkeley focuses on organometallic reaction mechanisms using ultra fast infrared spectroscopy. 

Organometallic chemistry has been a popular subject for the Nobel prize committee. In 1912 Grignard (Mg) won the award, in 1973 Wilkinson and Fischer for sandwich compounds (such as ferrocene), in 2005 Chauvin, Grubbs, and Schrock for alkene metathesis, and in 2010 Fleck, Negishi, and Suzuki (Stille had died in 1989) for transition-metal catalysed couplings. 

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