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Growth hormone binding affinity

Insulin-like growth factor-1 (IGF-1) is a peptide, 7649 Da, with structural homology to proinsulin. It binds preferentially to IGF-1 receptors on the surface of target cells. It has a lower affinity for insulin receptors. The receptors for insulin and IGF-1 share some structural and functional homology. IGF-1 is produced in the liver and in other organs in response to growth hormone action. IGF-1 that reenters the circulation is bound to... [Pg.387]

Pal, G., Kossiakoff, A. A., and Sidhu, S. S. (2003). The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alaninescanning mutagenesis Insights into the mechanisms responsible for improved affinity./ Mol. Biol. 332(1), 195-204. [Pg.168]

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See also in sourсe #XX -- [ Pg.160 ]



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