Griseofulvin Alcohol

GRISEOFULVIN ALCOHOL Disulfiram-like reaction can occur Uncertain Warn patients not to drink alcohol while taking griseofulvin... 

Fett DL, Vukov LF. An unusual case of severe griseofulvin-alcohol intemcticxi. Arm Emerg Med( 99A)24,95-l. 

Alcohol or substances with disulfiram effect (e.g. mushrooms, griseofulvin,sulfonyl urea)... 

Iodometric analysis has been applied to the determination of griseofulvin in stages of the manufacturing process (37). The mycelium is extracted with chloroform and the analysis carried out in alcoholic solution. The 0.01N iodine solution is standardized with griseofulvic acid. 

Drugs that may affect barbiturates include alcohol, charcoal, chloramphenicol, MAO inhibitors, rifampin, and valproic acid. Drugs that may be affected by barbiturates include acetaminophen, anticoagulants, beta blockers, carbamazepine, chloramphenicol, clonazepam, oral contraceptives, corticosteroids, digitoxin, doxorubicin, doxycycline, felodipine, fenoprofen, griseofulvin, hydantoins, methoxyflurane, metronidazole, narcotics, phenmetrazine, phenylbutazone, quinidine, theophylline, and verapamil. 

The psychiatric effects of griseofulvin can be very disturbing and are aggravated by alcohol (SED-12, 676) (291). 

The effects of alcohol are potentiated by griseofulvin, and the use of alcohol increases the risk and severity of psychiatric disturbances. 

Griseofulvin enhances the effects of alcohol and reduces the effectiveness of oral contraceptive pills. 

Another isolated case of flushing and tachycardia attributed to the concurrent use of alcohol and griseofulvin has also been described rechallenge produced the same effects. ... 

It has been suggested that griseofulvin can increase the effects of alcohol, but the descriptions of this response are very brief. One of them describes a man who had a decreased tolerance to alcohol and emotional instability manifested by crying and nervousness, which was said to be so severe that the drug was stopped. Another states that this effect has been noted in a very small number of patients, but gives no further information. 

The documentation is extremely sparse, which would seem to suggest that adverse interactions between alcohol and griseofulvin ate uncommon. Concurrent use need not be avoided but it may be prudent to warn patients about the possible effects. The disulfiram-like reaction described was unusually severe. The manufacturer cautions that the effects of alcohol may be potentiated by griseofulvin, producing such adverse effects as tachycardia and flush. ... 

An isolated case report describes a very severe disulfiram-like reaction when a man taking griseofulvin drank a can of beer. Another isolated report notes flushing and tachycardia. A few others have shown increased alcohol effects. 

Spirit of glyceryl trinitrate. See Nitroglycerin Spirit of Hartshorn. See Ammonium hydroxide Spirit of nitrous ether. See Ethyl nitrite Spirit orange. See Solvent yellow 14 Spirits of salt. See Hydrochloric acid Spirits of turpentine. See Turpentine Spirits of wine. See Alcohol Spirit of trinitroglycerin. See Nitroglycerin Spirit of turpentine. See Turpentine Spiro (benzofuran-2(3H), 1 -(2) cyclohexene)-3,4 -dione, 7-chloro-2, 4,6-trimethoxy-6 -p-methyl-. See Griseofulvin Spiro [bicycio [3.1.1] heptane-2,2 -oxirane], 6,6-dimethyl-. See Epoxypinane Spiro [1,3-dioxane-5,2 (2H)-napthalene], hexahydro-2,5, 5 -trimethyl-. See Dimethyl hexahydronaphthyl dihydroxymethyl acetal Spirofior. See 3-Ethyl-2,4-dioxaspiro (5.5) undec-8-ene... 

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