Grignard reagents with metal halides

Reactions of Grignard reagents with metal halides, usually chlorides or bromides, have been extensively used for the preparation of symmetrical triorganoantimony and... 

As the other synthetic method of organoruthenium compounds, the reaction of organolithium compounds or Grignard reagents with metal halides, which is the representative synthetic method of the main group organometallic compounds, is also available [25—28]. For example, organoalkali metal compounds react easily with ruthenium halides to form condensation products as shown in eq. (16.17) [25]. 

Selective cross-coupling reactions between C(sp ) and C(5p ) centers had been one of the most difficult tasks in carbon-carbon bond synthesis until the early 1970s, when it was first reported that iron, nickel, palladium and copper - catalysts are extremely effective for cross-coupling of Grignard reagents with organic halides. Now, nearly 20 years later, transition metal catalyz cross-coupling has become the reaction of first choice for this purpose. 

The need for a more efficient and a more versatile synthetic route to PPP was filled by Yamamoto et al. [50] in the late 1970s. Results indicating that transition metals or their complexes catalyze the coupling of Grignard reagents with aryl halides [51] were adapted... 

Among others, alkyls of Be, Cd, Hg, Al, Sn, Pb, Co, Pt, and Au have been prepared by treatment of Grignard reagents with the appropriate halide. The reaction has been used to prepare alkyls of almost all non-transition metals and even of some transition metals. Alkyls of metalloids and of nonmetals, including Si,... 

Reaction of a Grignard Reagent with a Metal Halide... 

In terms of their chemical behavior, dialkylzinc compounds generally react to transfer alkyl groups to other metals. Dialkyls of cadmium are usually prepared by the reaction of a Grignard reagent with a cadmium halide. 

Arylzinc reagents can be made from aryl halides with activated zinc118 or from Grignard reagents by metal-metal exchange with zinc salts.119... 

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