Grignard reagents with halides

Perfluoroalkylacecylenic tin compounds have been synthesized via the reaction of perfluoroalkylacetylenic Grignard reagents with tin halide derivatives [21] (equation 14) The stability of several of these perfluoroalkylacetylenic tin derivatives has been studied [22],... 

Polarization also occurs in coupling and disproportionation reactions of Grignard reagents with alkyl halides. The vinyl protons of isobutene produced in the reaction of t-butylmagnesium chloride with t-butyl bromide show A/E polarization as do the methyl protons of isobutane (Ward et al., 1970). Similar results arise in the reaction of diethyl-magnesium with organic halides (Kasukhin et al., 1972). 

Among others, alkyls of Be, Cd, Hg, Al, Sn, Pb, Co, Pt, and Au have been prepared by treatment of Grignard reagents with the appropriate halide. The reaction has been used to prepare alkyls of almost all non-transition metals and even of some transition metals. Alkyls of metalloids and of nonmetals, including Si,... 

Scheme 29 Iron-catalyzed cross coupling reaction of aryl Grignard reagents with alkyl halides...

Nickel(II) salts are able to catalyze the coupling of Grignard reagents with alkenyl and aryl halides. A soluble 6 -phosphine complex, Ni(dppe)2Cl2, is a particularly effective catalyst.266 The main distinction between this reaction and Pd-catalyzed cross... 

The stoichiometric reaction of organolithium or Grignard reagents with copper halides allows direct formation of organocopper species(103). 

Reaction of a Grignard Reagent with a Metal Halide... 

In terms of their chemical behavior, dialkylzinc compounds generally react to transfer alkyl groups to other metals. Dialkyls of cadmium are usually prepared by the reaction of a Grignard reagent with a cadmium halide. 

Decomposition of azo compounds and peroxides provides the alkoxyamine by the nitroxide-trapping of the primary radicals [29]. The radicals produced by hydrogen abstraction with oxy radicals are also trapped by the nitroxide [242, 243]. In the photoreaction, alkoxyamines were isolated with high yields [244]. The reactions of Grignard reagents with nitroxides [215] and the coupling reaction of sodium nitroxides with bromo compounds [234,235] are also used. The hydrolysis of 56 followed by the reaction with acyl or alkyl halides afforded alkoxyamines with various functional groups,63 (Eq. 68) [245-251] ... 

Preparation of bis(4-methoxyphenyl)phenylphosphine oxide — Reaction of a Grignard reagent with a phosphorus halide... 

Tetraalkyllead compounds can be obtained by reaction of Grignard reagents with lead(II) halides or by reaction of 3RLi and RI with PbX2. ... 

The heteroarylstannanes are usually prepared by the reaction of a heteroaryllithium or heteroaryl Grignard reagent with a tin(iv) halide, and all the simple examples in Table 3 have been prepared by this method. 

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