Greener Synthetic Methods in Primary Manufacturing

It is clear that if these aspirational E factor targets are to be met, then improvements are desirable in many areas of chemistry, including waste minimization in medicinal chemistry, greener synthetic methods in primary manufacture, increased use of chemo and biocatalysis, and more collaborative efforts between pharmaceutical companies. These areas are aU discussed in the remainder of this chapter. Although Sheldon focused on primary manufacture, it is also important to think about secondary manufacture (formulating tablets, capsules, or other dosage forms), which is also covered in this chapter. 

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