Granulomatous Lung Inflammation

University of Michigan Medical School Ann Arbor, Michigan, U.S.A. 

Kumamoto University School of Medicine Kumamoto, Japan 

Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016 

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Michielsen C, Leusink-Muis A, Vos JG, Bloksma N (2001) Hexachlorobenzene-induced eosinophilic and granulomatous lung inflammation is associated with in vivo airways hyperresponsiveness in the Brown Norway rat. Toxicol Appl Pharmacol, 172 11-20. 

Hypersensitivity Pneumonitis a group of respiratory diseases that cause inflammation of the lung (specifically granulomatous cells). Most forms of... 

HEALTH SYMPTOMS inhalation (cough, rhinitis, dyspnea, vomiting, cumulative lung damage) eye contact (induces granulomas in and about the eye, conjunctival inflammation) skin contact (can induce severe granulomatous reaction when introduced into wounds). 

Figure 11.6 Overview of the lung section of (a) control rat and (b) rat exposed to 2.5 mgm MWCNT. (c) is a detail view of focal granulomatous inflammation observed in a rat exposed to 0.1 mg m MWCNT, and (d) in a rat exposed to 2.5 mg m" MWCNT. (e) Lung section of a rat exposed to 2.5 mg m showing intra-alveolar eosinophilic granular material which was diagnosed as lipoproteinosis. (f) This intra-alveolar eosinophilic granular material was PAS-positive. Reproduced from L. Ma-Hock et aL, Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months, Toxicol. Sci, 2009,112, 2, with permission from Oxford University Press. ...

Sihcosis, due to the inhalation of crystalline tetrahedral (quartz, tridymite, cristobalite) - but not octahedral (stishovite) - silicon dioxide, is characterised by granulomatous inflammation of the lung. As in various granulomatous diseases, such as other pneumoconioses, sarcoidosis, and tuberculosis, sihcosis is characterised by an early mononuclear cell infiltration of the lung parenchyma followed by resident cell activation and proliferation (Becklake 1994). 

COPE with Cytokines. 2006. Available at http //www.copewithcytokines.de/. Kunitake R, Kuwano K, Miyazaki H, et al. Apoptosis in the course of granulomatous inflammation in pulmonary sarcoidosis. Eur Respir J 1999 13(6) 1329-1337. Agostini C, Zambello R, Sancetta R, et al. Expression of tumor necrosis factor-receptor superfamily members by lung T lymphocytes in interstitial lung diseases. Am J Respir Crit Care Med 1996 153 1359-1367. 

Figure 5 See color insert.) (A) Lung biopsy specimen of subacute hypersensitivity pneumonitis showing bronchiolocentric interstitial inflammation and poorly formed granulomas around bronchiole. (B) Interstitial granulomatous lesion in another field of the same patient. (C) Chronic interstitial inflammatory infiltrate and fibrosis in an HP patient with two years of progressive symptoms before hiopsy. Arrowhead shows a poorly formed granuloma. Abbreviation-. HP, hypersensitivity pneumonitis.

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