Granule blend homogeneity

Once the analytical method is validated for accuracy at the laboratory scale, it can be used to obtain extensive information on process performance (blend homogeneity, granulation particle size distribution, and moisture content) under various conditions (blender speed, mixing time, drying air temperature, humidity, volume, etc.). Statistical models can then be used to relate the observable variables to other performance attributes (e.g., tablet hardness, content uniformity, and dissolution) in order to determine ranges of measured values that are predictive of acceptable performance. 

Homogeneous, Granule, Blend, Mixture, Pesticide, Non-segregating... 

Achieve a homogeneously distributed API within the initial blend, prior to dry granulation Quality Blend sampling or stratified tablet core sampling Blend uniformity or tablet content uniformity... 

The wet granulation process is the traditional method of manufacture and is frequently used in the pharmaceutical industry. Expertise in wet granulation is widely available, as is the required equipment. The process improves flow and cohesion, reduces dust and crosscontamination, and permits the handling of powder blends without loss of homogeneity. 

Fig. 6.6-25 Flow diagram of a plant combining fertilizer bulk blending (2-7) and compaction/ granulation (8-27). 1, front-end loader input of components 2, 8, 18, bucket elevators 3, distributor 4, silos for components 5, compounding scale 6, blender 7, bulk blend receiving hopper (courtesy Sackett, Baltimore, USA). 9, mill for feed homogenization 10, feed bin 11, 27, screw conveyors 12, belt mixer 13, metal separators 14, 25,...

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