Gram-positive bacteria infections caused

Vancomycin (Vancocin) acts against susceptible gram-positive bacteria by inhibiting bacterial cell wall synthesis and increasing cell wall permeability. This drug is used in the treatment of serious gram-positive infections that do not respond to treatment with other anti-infectives. It also may be used in treating anti-infective-associated pseudomembranous colitis caused by Clostridium difficile. 

The sites of infections that most frequently led to sepsis were the respiratory tract (21% to 68%), urinary tract (14% to 18%), and intraabdominal space (14% to 22%). Sepsis may be caused by gram-negative (38% of sepsis) or gram-positive bacteria (40%), as well as by fungi (17%) or other microorganisms. 

Lincomycins bacteriostatic activity is based on the inhibition of the bacterial proteic synthesis. Lincomycin A in particular have been largely employed in clinical therapy of infections caused by micoplasmas, Gram-positive bacteria, and cocci but it presents a lot of side effects overcome by 7-clindamycin (Fig. 21), a semi-synthetic drug with larger spectrum of action and major antibacterial activity. 

Appelbaum PC, Jacobs MR. (2005) Recently approved and investigational antibiotics for treatment of severe infections caused by Gram-positive bacteria. Curr Opin Microbiol 8 510-517. 

Mastitis is nearly always caused by bacterial infection. The introduction of benzyl penicillin for the treatment of intramammary infections (IMI) caused by Gram positive bacteria, followed by products containing other antimicrobial agents, was a major advance in... 

Bacitracin is seldom used parenterally because renal necrosis has been reported after systemic use. Bacitracin is primarily used topically to treat skin and mucous membrane infections caused by gram-positive bacteria because only a few of these bacteria have become resistant to it. 

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