Graft-versus-host disease GvHD

The red cells also may be filtered to reduce the white cell content. This technique is needed if there is a chance of the patient developing graft versus host disease (GvHD), ie, transfused white cells attack the cells of the patient. 

Contamination of blood products with lymphocytes can lead to transfusion-induced reactions ranging from a mild fever to severe reactions such as alloimmunization and graft versus host disease (GvHD), in which the transfused lymphocytes (graft) survive the defensive immune reaction of the patient (host) and start a reaction which destroys the cells of the host. The patient also may develop an immune response to the human leukocyte antigen (HLA) type of the graft s cells and reject all platelet transfusions that do not match their own HLA system. The HLA system, found on blood platelets and lymphocytes, is more compHcated than, but similar to, the ABO blood group system of red cells. 

Explain graft-versus-host disease (GVHD). 

Recommend a prophylactic and treatment regimen for graft-versus-host disease (GVHD). 

Graft-versus-host disease (GVHD) is caused by the activation of donor lymphocytes leading to immune damage to the skin, gut, and fiver in the recipient. An immunosuppressive regimen is administered to prevent GVHD in recipients... 

In general, immunosuppression, expansion of regulatory cells, costimulatory blockade, or promotion of a Th2 cytokine milieu is considered to be supportive of disease control in T-cell regulatory disorders such as autoimmune disease and graft-versus-host disease (GvHD) [2]. In contrast, killer cells, a Thl cytokine milieu, or activated lymphocyte infusions support control of malignancy and infections. Maintaining a balance between the two... 

Jaffee, B.D. and Claman, H.N. (1983). Chronic graft versus host disease (GVHD) as a model for scleroderma. 1. Description of model systems. Cell Immunol. 77, 1-12. 

Allogeneic transplantation is complicated by the immune recognition of host tissues by donor T lymphocytes, resulting in a syndrome called graft-versus-host disease (GVHD). Because immune... 

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