Gordon, Mark

Another method that has been applied by our group to the study of enzymatic reactions is the Effective Fragment Potential (EFP) method [19]. The EFP method (developed at Mark Gordon s group at Iowa State University) allows the explicit inclusion of environment effects in quantum chemical calculations. The solvent, which may consist of discrete solvent molecules, protein fragments or other material, is treated explicitly using a model potential that incorporates electrostatics, polarization, and exchange repulsion effects. The solute, which can include some... 

Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA 2Department of Chemistry, Iowa State University, Ames, IA 50011, USA, e-mail mark si.msg.chem.iastate.edu (M.S. Gordon)... 

Submitted by Nicholas G. W. Rose, Mark A. Blaskovich, Ghotas Evindar, Scott Wilkinson, Yue Luo, Dan Fishlock, Chris Reid, and Gilles A. Lajoie. Checked by Richard S. Gordon and Andrew B. Holmes... 

Dermal/Ocular Effects. Very few reports mention any effect of carbon tetrachloride inhalation on the skin. Inhalation exposure to carbon tetrachloride for several days in the workplace caused a blotchy, macular rash in one man (but not in six others) (McGuire 1932). Similarly, a hemorrhagic rash occurred in a woman exposed to carbon tetrachloride fumes for several days in the workplace (Gordon 1944), and black and blue marks were seen in a patient exposed intermittently to carbon tetrachloride vapors for several years (Straus 1954). Because observations of dermal effects are so sporadic, it is difficult to judge whether these effects are related to carbon tetrachloride exposure, or are incidental. Conceivably, they may have been secondary to reduced synthesis of blood coagulation factors resulting from carbon tetrachloride-induced hepatotoxicity. No studies were located regarding ocular effects in humans or animals after inhalation exposure to carbon tetrachloride. 

I thank Mark Nandor, Dennis Gordon, Lon Richardson, Tej a Krasek, Jamie Forbes, David Jay Brown, Graham Cleverley, Pete Barnes, Steven Andersen, and members of the Clifford Pickover Think Tank for useful comments and suggestions ... 

The paper of Gordon describes a model for diffusion-controlled reaction based on the "hole concept in liquids of Jost (Ref 1, p 459). in which the activation energy for diffusion is equated simply to pV. The marked effect of density, therefore, results from the strong dependence of pressure on density (p varying about as the density cubed) and the appearance of this factor in an exponential term. On this basis, Gordon derived an approximate expression for dependence of detonation velocity D on explosive density pQ. This equation is given on pp 833 and 836 of Gordon s paper. From this expression the critical diameter dc for composite explosives is related to an exponential function of density by ... 

Wolf B, Freehaus CL, Thomas JA, Gordon PL, Greene CL, Ward JC (2003) Markedly elevated serum biotinidase activity may indicate glycogen storage disease type la. J Inherit Metab Dis... 

This 43rd volume of Advances in Organometallic Chemistry marks the transition of Professor F. Gordon A. Stone, F.R.S., C.B.E., to the status of Founding Editor of the series that he instigated and coedited for 34 years. 

H. F. Mark, S. M. Adas, and E. Cemia, eds., Man-Made Fibers Science and Technology, 3 Vols., Wiley-Interscience, New York, 1967—1968. Z. K. Walczak, Formation of Synthetic Fibers, Gordon Breach, New York, 1977. 

The author would like to thank SAPPI Fine Paper for financial support and Mr. Mark Gordon for help in preparing the manuscript. 

W Gordon Frankk, Mark Slifstein, Peter S. Talbot, and Marc Laruelle... 

Stephenson, K., Tunstead, J., Tsai, A., Gordon, R., Henderson, S., and Dansky, H. M. 2003. Neoin-timal formation after endovascular arterial injury is markedly attenuated in db/db mice. Arte-rioscler. Thromb. Vase. Biol. 23 2027-2033. 

I would like to thank Drs. Eric M. Gordon, Mikhail F. Gordeev and Jeff Jacobs at Versicor and Mark Gallop at Affymax for their valuable contributions toward establishing combinatorial chemistry as a critical drug discovery tool. 

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