Good modeling practice

Development of harmonized guidance regarding model validation criteria, good modeling practices and criteria for model-based assessments. 

This approach needs to be aligned with a revision of perceived Good Modeling Practice (GMP) which would require comments on the impact of model assumptions in a report on a particular exposure assessment or validation. Considering validation, the issue becomes a little more complex with the need to understand the potential impact of discrepancies between the potentially different sets of assumptions associated with the problem... 

Gentry, P. R., Clewell, H. J., and Andersen, M. E. (2004). Good Modeling Practices for Pharmacokinetic Models in Chemical Risk Assessment. Contract report submitted to Health Canada. 

Today, good modeling practices dictate that a data analysis plan (DAP) be written prior to any modeling being conducted and prior to any unblinding of the data. The reason being that model credibility is increased to outside reviewers when there is impartiality in the model development process. The DAP essentially provides a blueprint for the analysis. It should provide details... 

Thus, as follow-up actions of the LEMTOX workshop, it is planned to organize a workshop especially to develop guidelines for good modeling practice with the focus on pesticide registration and to develop well-documented examples (case studies) of model development, documentation, and application that can be used to offer training and a basis for further discussion for stakeholders and a wider user group in workshops and short courses. 

What Needs to Be Covered by Guidance on Good Modeling Practice .108... 

WHAT NEEDS TO BE COVERED BY GUIDANCE ON GOOD MODELING PRACTICE ... 

Model User Experience and Good Modelling Practice... 

Kell D B, Sonnleitner B (1995). GMP- good modelling practice An essential component of good manufacturing practice. Tibtech. 13 481-492. 

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