Gonadotropins observational study

Ismail AAA, Walker PL, Barth JH, Lewandowski KC, lones R, Burr WA. Wrong biochemistry results two case reports and observational study in 5310 patients on potentially misleading thyroid-stimulating hormone and gonadotropin immunoassay results. Clin Chem 2002 48 2023-9. 

XXX Type of Trisomy. Patients have been observed with duplicate sex chromatin bodies in the cells of the buccal mucosa, with resistant amenorrhea, infantile external genitalia, underdeveloped breasts, and high levels of urinary gonadotropins. Chromosome studies on cultured bone marrow cells demonstrated the presence of 47 chromosomes with the XXX type of trisomy. 

Gynecomastia was occasionally observed in men when ketoconazole first became available. Ketoconazole has a marked effect on steroid concentrations, including a change in the testosterone/estradiol ratio, and this is most likely to be the basis of the gynecomastia. A lowering of testosterone serum concentrations and a reduced response of testosterone concentrations to human gonadotropin have been shown (SED-11, 573) (583). Various studies have shown suppression of testosterone, androste-nedione, and dehydroepiandrosterone, with reciprocal increases in gonadotrophins. 

In addition to its effects on the molt interval previously described, there are observations that MF is a female gonadotropin. Early, indirect studies involved eyestalk ablation and subsequent ovarian maturation. For example, MOs (the... 

When weekly studies of this sort were made on a group of menopausal women, the return of gonadotropin excretion to normal values was observed without the appearance of increased estrogen activity (Figs. 4 and 5). It must be pointed out that increase in estrogenic activity was not observed even in patients with serious liver damage not modified by treatment. 

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