Gonadotropin-releasing hormone-associated

Abarelix is a gonadotropin-releasing hormone antagonist that is associated with life-threatening hypersensitivity reactions. Patients must be observed for 30 minutes after administration. The drug is limited to men who cannot risk tumor flare and refuse orchiectomy. 

Warnock JK, Bundren JC, Morris DW. Depressive symptoms associated with gonadotropin-releasing hormone agonists. Depress Anxiety 1998 7(4) 171-7. 

Figure 54-1 Schematic representation of steroid and protein hormone production by the placenta. DHEA-S, Dehydro-epiandrosterone sulfate CG, chorionic gonadotropin PL, placental lactogen ACTH, adrenocorticotropic hormone TRH, thyroid-stimulating hormone CT, chorionic thyrotropin GnRH, gonadotropin-releasing hormone CRH, corticotropin-releasing hormone PAPP-A, pregnancy associated plasma protein-A.

Vercellini P, Trespidi L, Colombo A, et al. A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril 1993 60 75-79. 

Lam C, Tjon J, Hamilton J, Ahmet AH. Recurrent anaphylaxis associated with Gonadotropin-Releasing hormone analogs case report and review of the literature. Pharmacotherapy 2006 26(12) 1811-5. 

Casper, R.F. (1991) Chnical uses of gonadotropin-releasing hormone analogues. Canadian Medical Association Journal, 144,153-158. 

The gonadotropins, FSH and LH, are large glyooproteins released by the anterior pituitary on stimulation from GnRH produoed by the hypothalamus. Both FSH and LH consist of two noncovalently associated a and p subunits. The a subunits both oontain 92 amino aoids and are identical in both hormones, whereas the p subunit in LH oonsists of 121 residues and 111 residues in FSH, with the p subunits being dissimilar (52). Thus, the p subunit gives eaoh hormone its specific function. 

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