Gonadorelin and analogues

Hormones and analogues growth hormone corticotrophin (ACTH) calcitonin desmopressin (DD AVP) lypressin oxytocin buserelin nafarelin progesterone norethisterone 17/1-estradiol testosterone insulin Gonadorelin (Gonadotrophin-releasing hormone GnRH LH-RH)... 

Gonadotropins (gonadorelin, GnRH, and analogues) [SED-15, 1536 SEDA-31, 703 SEDA-32, 789 SEDA-33, 909]... 

GONADOTROPINS (GONADORELIN, GnRH AND ANALOGUES) fSED-15, 1536 SEDA.33, 909 SEDA-34, 703 SEDA-35, 789] ... 

Prostatic cancer is androgen-dependent and metastatic disease can be helped by orchidectomy, or by a gonadorelin analogue, e.g. buserelin, goserelin, leuprorelin or triptorelin. These cause a transient stimulation of luteinising hormone and thus testosterone release, before inhibition occurs some patients may experience exacerbation of tumour effects, e.g. bone pain, spinal cord compression. Where this can be anticipated, prior orchidectomy or antiandrogen treatment, e.g. with cyproterone or flutamide, is protective. 

Spironolactone (p. 534) also has antiandrogen activity and may help hirsutism in women. Androgen secretion may be diminished by continued use of a gonadorelin (LH-RH) analogue (see p. 714). 

Buserelin is an analogue of the hypothalamic hormone, gonadotrophin-releasing hormone (gonadorelin). In chronic use it reduces pituitary secretion of gonadotrophin, which results in reduced secretion of sex hormones by the ovaries or testes. Buserelin is used to treat endometriosis, and also as an anticancer agent for cancer of the prostate gland. It is also used prior to in vitro fertilization. 

U 69689) is a synthetic peptide analogue of gonadorelin (gonadotrophin-releasinghormone), a potent lh-rh RECEPTOR AGONIST with simiiar properties. It can be used in the treatment of gonadal steroid-dependent diseases and infertility in women. For further detail see gonadotrophinreleasing hormone, fertirelin acetate fertirelin. 

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