Gonadal hormones inhibitors

Moon face is a manifestation of hypercortisohsm, not adrenal insufficiency. The answer is (B). A rational combination of drugs should include agents with complementaiy effects, ie, a glucocorticoid and a mineralocorticoid. The combination with these characteristics is cortisol and fludrocortisone. (Note that while fludrocortisone may have sufficient glucocorticoid activity for a patient with mild disease, a patient in severe acute adrenal insufficiency needs a full glucocorticoid such as cortisol.) The answer is (B). 

Corticosteroids are more effective than NSAIDs in controlling acute severe flare-ups of joint inflammation. However, the severe toxicities of corticosteroids (adrenocortical suppression, weight gain, buffalo hump, striae, osteoporosis, diabetes, peptic ulcers, cataracts, glaucoma, and psychoses) preclude their use for chronic therapy in most patients. 

Older disease-modifying antirheumatic drugs (DMARDs) used frequently in rheumatoid arthritis include hydroxychloroquine, methotrexate, steroids, and sulfasalazine. Gold salts and penicillamine may be effective but cause severe toxicity (see Chapter 36). 

Newer drugs that have become available for the treatment of rheumatoid arthritis include the COX-2 inhibitors, etanercept, infliximab, and leflunomide (see Chapter 36). 

Describe the hormonal chtinges that occur during the menstrual cycle. 

---

Chapter 39 Adrenocorticosteroids Adrenocortical Antagonists Chapter 40 The Gonadal Hormones Inhibitors Chapter 41 Pancreatic Hormones Antidiabetic Drugs Chapter 42 Agents That Affect Bone Mineral Homeostasis... 

AccessMedicine Print Chapter 40. The Gonadal Hormones Inhibitors... 

Katzung PHARMACOLOGY, 9e > Section VII. Endocrine Drugs > Chapter 40. The Gonadal Hormones Inhibitors >... 

---