Gold complexes amines

Thiirane is more bactericidal than oxirane, and derivatives of 2-mei captomethylthiirane inhibit tuberculosis. The following pharmacological uses have been reported for compounds derived from thiirane derivatives gold complexes of the adducts of diethylphosphine and thiirane (antiarthritic), adducts of thiiranes and malononitrile (antibacterial, blood vessel dilators, muscle relaxants, sedatives), thermolysis products of thiirane 1-oxides and adducts of thiirane 1-oxides with sulfenyl chlorides (antibacterial), adducts of 2,3-diarylthiirene 1,1-dioxides with ynamines (antibacterial, parasiticidal), adducts of 2,3-diarylthiirene 1,1-dioxides with enamines (antifertility), adducts of p-aminophenylacetic esters with thiirane (immunosuppressants), adducts of amines and thiiranes (radioprotective drugs). 

The Au(ll) oxidation state was also observed in cyclometalated gold dimers [386, 387] and in gold complexes of hA(diphenylphosphino)amine [388]. The specific feature of these Au(ll) complexes is that their 6 - A q relation is located midway between that of Au(l) and Au(lll) complexes. 

Early work focused on compounds with open-chain carbenes generally synthesized in the coordination sphere of the gold atom, for example, by addition of amines or alcohols to isocyanide ligands in the corresponding gold complexes. Subsequent synthetic approaches have relied on the in situ deprotonation of onium salt precursors by a... 

Carbenes are speties with a divalent carbon atom with various substituents and a lone pair of electrons. Classic carbene gold complexes were synthesized in the coordination sphere of the gold atom, addition of amines or alcohols to the coordinated isocyanide ligands. N-Heterocyclic carbenes (Arduengo s carbenes)... 

Similar to the abovementioned silver nhc coordination compounds, carbene chemistry has also been dominant in the field of gold organometallic chemistry. Noteworthy examples include a Au(PPh3)-compound derived from tetraaminoallene, that can be rationalised in terms of a dicarbene with ylide character and which, owing to the electron-rich character of the central carbon atom, offers the potential for dimetallation products.108 Non-activated allenes and alkynes have been found by Lavallo to be readily aminated by cationic carbene gold complexes.109 For this purpose, a 2,6-diisopropylphenyl functionalized cyclic alkylaminocarbene gold(I) complex... 

On the other hand, novel photosensitizers were synthesized and applied in the visible-light-mediated oxidative hmctionalization of A-Aryl tetrahydroisoquinolines. A promising organogold complex was developed for aerobic oxidative C (sp )-H functionalization of secondary and tertiary amines (Scheme 3.5) [31]. Another feature of this novel gold complex was imderUned by production of... 

The CAAC gold complex 43a catalysed the amination of terminal and internal alkynes (Scheme 5.8)." When using ammonia or a primary amine as substrate, imines were the major product. For ammonia fixation, the reaction was also successfully carried out using the preformed ammonia complex 43b as... 

For the synthesis of Al-substituted 2,5-dimethylpyrroles, triazole-gold complex, Au-II, showed excellent catalytic activity toward the hydroamination with primary amines [17] ... 

Also in 2009, Belot et al. achieved a tandem reaction combining a secondary amine and a gold complex catalyst for the facile synthesis of densely substituted chiral tetrahydrofurans [47]. The reaction comprised a secondary amine-promoted MichaeladditionandanAu-catalyzedacetalization/cyclizationprocess(Scheme9.53). 

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