Goats intramuscular injection

After a single oral or intravenous administration of tetracycline to chickens at dosage rates of 100 mg/kg or 20 mg/kg bw, respectively, residue concentrations in muscle, kidney, and liver tissues were 0.03, 0.13, and 0.05 ppm, respectively, at 5 days posttreatment (248). Following intramuscular injection of tetracycline and oxytetracycline to goats at a dosage of 15 mg/kg bw at 24 h intervals for 4 days, residual levels of both drugs could be found in milk by day 4 after the last administration (249). The concentration of tetracycline at this time was 0.913 ppm, while that of oxytetracycline was 0.459 ppm in the milk. 

Various animal species can be used for antibody preparation rabbits are used most often, and goats for larger scale operations. For the first injection using complete Freund s adjuvant, intramuscular injection is recommended, whereas subsequent injections with incomplete Freund s adjuvant are carried out subcutaneously. 

Amoxicillin is widely distributed in body tissues and its metabolism is limited. Excretion of amoxicillin is tlirough the kidney, resulting in high concentrations in both the kidney tissue and urine, where the levels may be 100-fold higher than that in serum. Concentrations in milk are 10 times lower than those in serum. Following intramuscular or subcutaneous injection to goats, levels of amoxicillin in milk were very close to the detection limit of 10 ppb within 24 h after the last dose (65). 

In calves given oral, intramuscular or intramammary doses of trimethoprim, total residues in all edible tissues fell well below 100 ppb by the 7 day after the last dose. In lactating cows intramammary infusions of 40 mg trimethoprim/ quarter for three consecutive milkings resulted in mean residue concentrations in milk of 4749 ppb at 6 h after the first infusion, which declined to 215 ppb at 12 h after the first infusion. Twelve h after the second infusion, mean residue concentrations were 70 ppb. Six h after the last infusion, mean residue concentrations in milk were 2805 ppb whereas 18 h later, mean residue concentrations were 32 ppb. In goats given a single intravenous injection of 13 mg trimethoprim/ kg bw, mean residue concentrations in muscle, liver, and kidney were 1100, 800, and 2100 ppb 3 h later. 

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