Glycyrrhizin structure

Fig. 2 Chemical structures of glycyrrhizin and of the sweet glycosides of Stevia rebaudiana Bert and relative sweetness of stevia glycosides compared to sucrose (4%) ...

Several naturally occurring triterpenes have been reported to show anti-HIV activity, e.g. betulinic acid, platanic acid, glycyrrhizin, mimusopic acid, gano-deriol and geumonoid.16 20 These active compounds hold the potential to serve as hits or leads for anti-HIV drug development.21,22 The focus of this chapter is bevirimat, the first in a new class of compounds termed HIV maturation inhibitors (Mis). Our discussion covers modification, structure-activity relationship (SAR), mechanism of action studies and clinical trials of bevirimat. 

Fig. (4 a). The structure-activity relationship of glycyrrhizin (GLR)-derivatives blended with (closed symbols) or without (open symbols) paeoniflorin (PF) on the phrenic nerve-stimulated twitch response in mouse diaphragm. Percentage inhibition of twitch responses is plotted against the log-concentration of the GLR-derivative. PF was combined with GLR or GLR-related compounds at the same molar ratio of concentrations. I deoxyglycyrrhetol dihemisuccinate disodium, 11 deoxyglycyrrhetol dihemiphthalate disodium, and III glycyrrhetinic acid hemiphthalate disodium. 

Fig. 3.36 Chemical structures of glycyrrhetinic acid (R=H), glycyrrhizinic acid, and carbenoxo-lone. (Authors own work)...

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