Acidic glycosphingolipids

Phosphosphingolipids Phosphonosphingolipids Neutral glycosphingolipids Acidic glycosphingolipids... 

Glycosphingolipids are catabolized by the stepwise hydrolysis of the terminal monosaccharides through the concerted action of a series of specific exoglycosidases (Fig. 10) [12]. There is often a requirement for SAPs, SAP-A, -B, -C, or -D, and GM2-activator protein, which is required for GM2 hydrolysis but can also accommodate other glycosphingolipids. Acidic lipids, and in particular BMP, are additionally involved in vivo as stimulators of glycosidase activity and are components of the lysosomal perimeter membrane. 

Rhodamine 6G long-chain hydrocarbons [169] squalene, a-amyrin [170] methyl esters of fatty acids [171] glycerides [91] sterols [172, 173] isoprenoids, quinones [HI] lipoproteins [174] glycosphingolipids [175] phenolic lipids [176] phosphonolipids [177] increasing the sensitivity after exposure to iodine vapor [178,179]... 

FIGURE 9.4 TLC-blotting/SIMS of various glycosphingolipids. (A) TLC profile of the separated glycosphingolipids, (B) MS profiles obtained by TLC-blotting/SIMS (a) spectrum of sulfatide peaks at m/z 862, 876, 890, 906, and 918 are molecular ions with different fatty acid species indicated in the figure (asterisks are peaks of triethanolamine as matrix) (b) spectrum of Gb Cer peaks at m/z 1309 and 1337 are molecular ions with different fatty acid species as indicated (c) spectrum of G peaks at m/z 1151, 1235, and 1263 are molecular ions with different fatty acid species as shown. Abbreviations LCB — long chain base, FA — fatty acid, hFA — hydroxyfatty acid. Hex — hexose, HexNAc — /V-acetylhexosamine. (From Taki, T. et al.. Anal. Biochem., 225, 24—27, 1995. With permission.) Continued. 

De Rosa, M. F., Sillence, D.,Ackerley, C. and Lingwood, C. Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. /. Biol. Chem. 279 7867-7876, 2003. 

Gangliosides are a class of glycosphingolipid characterized by the presence of one or more sialic acid residues. They are located in the cell membranes, particularly in the plasma membrane, of almost all cell types. They are anchored in the membranes through their ceramide moiety and have the polar sugar-containing group in the extracytoplasmic side. They are particularly abundant in the nervous system where their expression pattern is modulated during development. 

Labyrin- thomorpba Thrausto- chytriaies 0/30 Mar. FATTY ACIDS docosahexaenoic acid. MDC. BIOGEN. glycosphingolipids Jenkins 1999 medi- um low... 

Glycosiduronic acids, of animals, 9, 185-246 poly-, of plants, 1, 329-344 Glycosphingolipids, 24, 381-433 Glycosones, 3-deoxy-. See Glycosuloses, 3-deoxy-. 

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