Glycosaminoglycan matrix formation

Carbohydrates and fatty acids are also necessary for rapid and good-quality skin regeneration. The extracellular matrix is made up of glycosaminoglycans and proteoglycans, which are polysaccharides linked to proteins. Omega-6 fatty acids are essential for cell membrane formation. Supplements of linoleic and linolenic acid can be recommended when the patient s blood is not properly balanced. ... 

The underlying mechanism by which glycosaminoglycans allow for the formation of a gel-like substance in the extracellular matrix in which of the following ... 

Wu and co-workers [13] incorporated copolymer poly(3HB-co-3HV) with calcium silicate(s) (CS) to increase the hydrophilicity of the copolymer in order to enhance cell adhesion on scaffolds used for cartilage tissue engineering. Interactions between poly(3HB-co-3HV)/CS composite scaffolds and chondrocytes in vitro and the formation of neocartilage were evaluated after the implantation of scaffolds into rabbits. It was found that the adhesion of chondrocytes onto the scaffolds and cell proliferation improved with the addition of CS. Enhanced penetration of chondrocytes into the scaffolds was observed with the increase in hydrophilicity of the poly(3HB-co-3HV)/CS composite scaffolds. A higher amount of collagen and glycosaminoglycan were detected in the composite scaffold compared with pure poly(3HB-co-3HV), indicating that poly(3HB-co-3HV)/CS composite scaffolds stimulated the extracellular matrix synthesis of chondrocytes. 

---