Phosphorylcholine glycoproteins

Haslam, S.M., Khoo, K-H., Houston, K.M., Harnett, W., Morris, H.R. and Dell, A. (1997) Characterisation of the phosphorylcholine-containing A-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae. Molecular and Biochemical Parasitology 85, 53—66. 

Harnett, W., Deehan, M.R., Houston, KM. and Harnett, M.M. (1999a) Immunomodulatory properties of a phosphorylcholine-containing secreted filarial glycoprotein. Parasite Immunology 21, 601-608. 

Houston, K.M. and Harnett, W. (1999a) Attachment of phosphorylcholine to a nematode glycoprotein. Trends in Glycoscience and Glycotechnology 11, 43-52. 

Houston, KM. and Harnett, W. (1999b) Mechanisms underlying the transfer of phosphorylcholine to filarial nematode glycoproteins - a possible role for choline kinase. Parasitology 118, 311-318. 

Houston KM, Cushley W, Harnett W (1997) Studies on the site and mechanism of attachment of phosphorylcholine to a filarial nematode secreted glycoprotein. J Biol Chem 272 1527-1533... 

Stepek G, Auchie M, Tate R et aL Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific. Parasitology 2002 125(Pt 2) 155-164. 

Harnett W, Harnett MM, Byron O. Structural/funaional aspects of ES-62—a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein. Curr Protein Pept Sci 2003 ... 

Wilson EH, Katz E, Goodridge HS et al. In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62. Parasite Immunol 2003 25(8-9) 463-466. 

MeInnes IB, Leung BP, Harnett M et al. A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. J Immunol 2003 171(4) 2127-2133. 

The molecule was first discovered as a 62 kDa foctor in excretory/secretory products (ES-62) of Acanthocheilonema viteae, a filarial nematode of rodents in 1989 by Harnett et ah It was also identified in other filarial nematode species that can cause severe human morbidity, such as Wuchereria bancrojii, Brugia malayi and Onchocerca volvulus. ES-62 is a phosphorylcholine (PC) containing glycoprotein that has been widely investigated as an immunomodulatory molecule. The active native molecule of ES-62 contains PC moieties that are modified by posttranslational processes. ... 

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