Glycoproteins, carriers

Drug/substrate Glycoprotein carrier-glycoconj ugates Species... 

L. Fiume, C. Busi, G. Di Stefano, and A. Mattioli, Targeting of antiviral drugs to the liver using glycoprotein carriers, Adv. Drug Deliv. Rev. 14 51 -65 (1994). 

The GIT supplements the kidney in the elimination of wastes and toxins. The P-glycoprotein of enterocytes, which is implicated in multi-drug resistance, plays a critical role. This export carrier exhibits varying responses to the different polyphenols present in green tea (Wang et al, 2002), and is inhibited by one or more components of grapefruit juice (Wagner et al, 2001). It is... 

Poorly absorbed compounds have been identified as those with a PSA>140Af Considering more compounds, considerable more scatter was found around the sigmoidal curve observed for a smaller set of compounds [74]. This is partly due to the fact that many compounds do not show simple passive diffusion only, but are affected by active carriers, efflux mechanisms involving P-glycoprotein (P-gp) and other transporter proteins, and gut wall metabohsm. These factors also con-... 

Krupka, R. M., Uncoupled active transport mechanisms accounting for low selectivity in multidrug carriers P-glycoprotein and SMR antiporters,... 

Keywords Colon Controlled release Sustained release Rat Single-pass perfusion Recirculation Closed loop Carrier-mediated transport Passive transport Membrane permeability P-glycoprotein Paracellular pathway Transcellular pathway... 

Deferme S, Van Gelder J, Augustijns P (2002a) Inhibitory effects of fruit extracts on P-glycoprotein-related efflux carriers An in-vitro screening. J Pharm Pharmacol 54 1-7. 

The existence of a carrier-mediated transport in nasal mucosa was first suggested by Kimura et al. [34], P-glycoprotein, organic cation transporter, dopamine transporter, and amino acid transporters have all been identified in the nasal mucosa, especially in the olfactory mucosa [31, 32, 35, 36], These transporters determine the polarized absorption and excretion of their substrates including amino acids, amines, and cations. 

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