Glycopolymers multivalent binding

Polypeptide-Based Glycopolymers for the Study of Multivalent Binding Events R. Maheshwari, S. Liu, B.D. Polizzotti, Y. Wang, and K.L. Kiick... 

Polypeptide-Based Glycopolymers for the Study of Multivalent Binding Events... 

In a subsequent investigation by the author [ 1 ] multivalent glycopolymers with chain-terminating binding groups, (I), were prepared and used in carbohydrate-mediated biomolecular recognition processes. 

Neoglycoproteins, liposomes, and glycopolymers have been successfully used to demonstrate that multivalency does indeed amplify carbohydrate-protein binding interactions by factors as high as thousands. However, by their very nature, these neoglycoconjugates have ill-defined chemical structures. They are heterogeneous in size and carbohydrate contents. Additionally, neoglycoproteins have been shown to... 

Glycodendrimers are mainly considered in various biomedical fields [39b] because of their high biocompatibility in combination with multivalency and specific interactions that are important, for example, for protein and cell membrane binding and recognition processes. The use of glycopolymers as viral and bacterial antiadhesion drugs and for inhibition of infections is very prominent (see also Sections 6.2 and 6.3). 

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